Structural progression of Alzheimer's disease over decades: The MRI staging scheme
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | PLANCHE, Vincent | |
| hal.structure.identifier | ITACA | |
| hal.structure.identifier | Universitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia [UPV] | |
| dc.contributor.author | MANJON, Jose V. | |
| hal.structure.identifier | Laboratoire Bordelais de Recherche en Informatique [LaBRI] | |
| dc.contributor.author | MANSENCAL, Boris
IDREF: 228223601 | |
| hal.structure.identifier | Universitat de València [UV] | |
| dc.contributor.author | LANUZA, Enrique | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | TOURDIAS, Thomas | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | CATHELINE, Gwenaelle | |
| hal.structure.identifier | Laboratoire Bordelais de Recherche en Informatique [LaBRI] | |
| dc.contributor.author | COUPE, Pierrick | |
| dc.date.accessioned | 2023-01-31T15:03:12Z | |
| dc.date.available | 2023-01-31T15:03:12Z | |
| dc.date.issued | 2022-04-28 | |
| dc.identifier.issn | 2632-1297 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/171832 | |
| dc.description.abstractEn | The chronological progression of brain atrophy over decades, from pre-symptomatic to dementia stages, has never been formally depicted in Alzheimer's disease. This is mainly due to the lack of cohorts with long enough MRI follow-ups in cognitively unimpaired young participants at baseline. To describe a spatiotemporal atrophy staging of Alzheimer's disease at the whole-brain level, we built extrapolated lifetime volumetric models of healthy and Alzheimer's disease brain structures by combining multiple large-scale databases (n = 3512 quality controlled MRI from 9 cohorts of subjects covering the entire lifespan, including 415 MRI from ADNI1, ADNI2 and AIBL for Alzheimer's disease patients). Then, we validated dynamic models based on cross-sectional data using external longitudinal data. Finally, we assessed the sequential divergence between normal aging and Alzheimer's disease volumetric trajectories and described the following staging of brain atrophy progression in Alzheimer's disease: (i) hippocampus and amygdala; (ii) middle temporal gyrus; (iii) entorhinal cortex, parahippocampal cortex and other temporal areas; (iv) striatum and thalamus and (v) middle frontal, cingular, parietal, insular cortices and pallidum. We concluded that this MRI scheme of atrophy progression in Alzheimer's disease was close but did not entirely overlap with Braak staging of tauopathy, with a 'reverse chronology' between limbic and entorhinal stages. Alzheimer's disease structural progression may be associated with local tau accumulation but may also be related to axonal degeneration in remote sites and other limbic-predominant associated proteinopathies. © 2022 The Author(s). Published by Oxford University Press on behalf of the Guarantors of Brain. | |
| dc.description.sponsorship | Apprentissage profond pour la volumétrie cérébrale : vers le BigData en neuroscience - ANR-18-CE45-0013 | en_US |
| dc.description.sponsorship | Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Alzheimer | |
| dc.subject.en | MRI | |
| dc.subject.en | Atrophy | |
| dc.subject.en | Lifespan | |
| dc.subject.en | Staging | |
| dc.title.en | Structural progression of Alzheimer's disease over decades: The MRI staging scheme | |
| dc.title.alternative | Brain Commun. | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/braincomms/fcac109 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35592489 | en_US |
| bordeaux.journal | Brain Communications | en_US |
| bordeaux.volume | 4 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.team | Relations glie-neurone | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation Bettencourt Schueller | en_US |
| bordeaux.identifier.funderID | Ministerio de Economía y Competitividad | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain%20Communications&rft.date=2022-04-28&rft.volume=4&rft.issue=3&rft.eissn=2632-1297&rft.issn=2632-1297&rft.au=PLANCHE,%20Vincent&MANJON,%20Jose%20V.&MANSENCAL,%20Boris&LANUZA,%20Enrique&TOURDIAS,%20Thomas&rft.genre=article |
