Five-Year Symptom Trajectories in Nondialysis-Dependent CKD Patients.
| dc.rights.license | open | en_US |
| dc.contributor.author | FAYE, Moustapha | |
| dc.contributor.author | LEGRAND, Karine | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | LE GALL, Lisa
IDREF: 222223472 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LEFFONDRE, Karen | |
| dc.contributor.author | OMOROU, Abdou Y | |
| dc.contributor.author | ALENCAR DE PINHO, Natalia | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | COMBE, Christian | |
| dc.contributor.author | FOUQUE, Denis | |
| dc.contributor.author | JACQUELINET, Christian | |
| dc.contributor.author | LAVILLE, Maurice | |
| dc.contributor.author | LIABEUF, Sophie | |
| dc.contributor.author | MASSY, Ziad A | |
| dc.contributor.author | SPEYER, Elodie | |
| dc.contributor.author | PECOITS FILHO, Roberto | |
| dc.contributor.author | STENGEL, Bénédicte | |
| dc.contributor.author | FRIMAT, Luc | |
| dc.contributor.author | AYAV, Carole | |
| dc.date.accessioned | 2023-01-16T14:57:12Z | |
| dc.date.available | 2023-01-16T14:57:12Z | |
| dc.date.issued | 2022-11-01 | |
| dc.identifier.issn | 1555-905X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/171692 | |
| dc.description.abstractEn | Late stages of CKD are characterized by significant symptom burden. This study aimed to identify subgroups within the 5-year trajectories of symptom evolution in patients with CKD and to describe associated patient characteristics and outcomes. Among 2787 participants (66% men) with eGFR <60 ml/min per 1.73 m enrolled in the CKD-Renal Epidemiology and Information Network (CKD-REIN) cohort study from July 2013 to May 2016, we assessed symptoms annually using the Kidney Disease Quality of Life-36 (KDQOL-36) questionnaire until December 2020. A total of 9121 measures were reported over follow-up; all participants had symptoms scored for at least one time point. We used a joint latent class-mixed model to distinguish profiles of symptom trajectories. Patient mean age (±SD) at baseline was 67±13 years, and mean eGFR was 33±13 ml/min per 1.73 m. The prevalence of each symptom ranged from 24% (chest pain) to 83% (fatigue), and 98% of participants reported at least one symptom. After a median (interquartile range) follow-up of 5.3 (3.4-6.0) years, 690 participants initiated KRT, and 490 died before KRT. We identified two profiles of symptom trajectories: a "worse symptom score and worsening trajectory" in 31% of participants, characterized by a low initial symptom score that worsened more than ten points over time, and a "better symptom score and stable trajectory" in 69% of participants, characterized by a high initial score that remained stable. Participants in the worse symptom score and worsening trajectory group had more risk factors for CKD progression at baseline, worse quality of life, and a higher risk of KRT and death before KRT than other participants. This study highlights a significant worsening of symptoms in about one third of the participants, whereas the majority reported low symptom severity throughout the study. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Male | |
| dc.subject.en | Humans | |
| dc.subject.en | Middle Aged | |
| dc.subject.en | Aged | |
| dc.subject.en | Aged | |
| dc.subject.en | 80 and over | |
| dc.subject.en | Female | |
| dc.subject.en | Cohort Studies | |
| dc.subject.en | Renal Insufficiency | |
| dc.subject.en | Chronic | |
| dc.subject.en | Quality of Life | |
| dc.subject.en | Risk Factors | |
| dc.subject.en | Surveys and Questionnaires | |
| dc.title.en | Five-Year Symptom Trajectories in Nondialysis-Dependent CKD Patients. | |
| dc.title.alternative | Clin J Am Soc Nephrol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.2215/CJN.06140522 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| dc.identifier.pubmed | 36307136 | en_US |
| bordeaux.journal | Clinical Journal of the American Society of Nephrology | en_US |
| bordeaux.page | 1588-1597 | en_US |
| bordeaux.volume | 17 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | |
| bordeaux.issue | 11 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.institution | CHU de Bordeaux | |
| bordeaux.institution | Institut Bergonié | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Journal%20of%20the%20American%20Society%20of%20Nephrology&rft.date=2022-11-01&rft.volume=17&rft.issue=11&rft.spage=1588-1597&rft.epage=1588-1597&rft.eissn=1555-905X&rft.issn=1555-905X&rft.au=FAYE,%20Moustapha&LEGRAND,%20Karine&LE%20GALL,%20Lisa&LEFFONDRE,%20Karen&OMOROU,%20Abdou%20Y&rft.genre=article |
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