A total closed chest sheep model of cardiogenic shock by percutaneous intracoronary ethanol injection.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | RIENZO, Mario | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | IMBAULT, Julien | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | EL BOUSTANI, Younes | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | BEURTON, Antoine | |
| dc.contributor.author | CARLOS SAMPEDRANO, Carolina | |
| dc.contributor.author | PASDOIS, Philippe | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | PERNOT, Mathieu | |
| dc.contributor.author | BERNUS, Olivier | |
| dc.contributor.author | HAÏSSAGUERRE, Michel | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | COUFFINHAL, Thierry | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | OUATTARA, Alexandre | |
| dc.date.accessioned | 2023-01-12T10:59:39Z | |
| dc.date.available | 2023-01-12T10:59:39Z | |
| dc.date.issued | 2020-07-24 | |
| dc.identifier.issn | 2045-2322 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/171662 | |
| dc.description.abstractEn | To develop a reproducible and stable closed chest model of ischemic cardiogenic shock in sheep, with high survival rate and potential insight into human pathology. We established a protocol for multi-step myocardial alcoholisation of the left anterior descending coronary artery by percutaneous ethanol injection. A thorough hemodynamic assessment was obtained by invasive and non-invasive monitoring devices. Repeated blood samples were obtained to determine haemoglobin and alcohol concentration, electrolytes, blood gas parameters and cardiac troponin I. After sacrifice, tissue was excised for quantification of infarction and histology. Cardiogenic shock was characterized by a significant decrease in mean arterial pressure (- 33%), cardiac output (- 29%), dP/dt (- 28%), carotid blood flow (- 22%), left ventricular fractional shortening (- 28%), and left ventricle end-systolic pressure-volume relationship (- 51%). Lactate and cardiac troponin I levels increased from 1.4 ± 0.2 to 4.9 ± 0.7 mmol/L (p = 0.001) and from 0.05 ± 0.02 to 14.74 ± 2.59 µg/L (p = 0.001), respectively. All haemodynamic changes were stable over a three-hour period with a 71% survival rate. The necrotic volume (n = 5) represented 24.0 ± 1.9% of total ventricular mass. No sham exhibited any variation under general anaesthesia. We described and characterized, for the first time, a stable, reproducible sheep model of cardiogenic shock obtained by percutaneous intracoronary ethanol administration. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Arterial Pressure | |
| dc.subject.en | Cardiac Output | |
| dc.subject.en | Coronary Circulation | |
| dc.subject.en | Coronary Vessels | |
| dc.subject.en | Disease Models | |
| dc.subject.en | Animal | |
| dc.subject.en | Ethanol | |
| dc.subject.en | Female | |
| dc.subject.en | Humans | |
| dc.subject.en | Injections | |
| dc.subject.en | Intra-Arterial | |
| dc.subject.en | Reproducibility of Results | |
| dc.subject.en | Sheep | |
| dc.subject.en | Shock | |
| dc.subject.en | Cardiogenic | |
| dc.subject.en | Survival Rate | |
| dc.subject.en | Ventricular Function | |
| dc.subject.en | Left | |
| dc.title.en | A total closed chest sheep model of cardiogenic shock by percutaneous intracoronary ethanol injection. | |
| dc.title.alternative | Sci Rep | en_US |
| dc.type | Article de revue | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 32709984 | en_US |
| bordeaux.journal | Scientific Reports | en_US |
| bordeaux.page | 12417 | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2020-07-24&rft.volume=10&rft.issue=1&rft.spage=12417&rft.epage=12417&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=RIENZO,%20Mario&IMBAULT,%20Julien&EL%20BOUSTANI,%20Younes&BEURTON,%20Antoine&CARLOS%20SAMPEDRANO,%20Carolina&rft.genre=article |
