The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | PIETROPAOLO, Susanna | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MARSICANO, Giovanni | |
| dc.date.accessioned | 2023-01-11T10:51:42Z | |
| dc.date.available | 2023-01-11T10:51:42Z | |
| dc.date.issued | 2022-01 | |
| dc.identifier.issn | 0149-7634 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/171654 | |
| dc.description.abstractEn | Recent years have seen an impressive amount of research devoted to understanding the etiopathology of Autism Spectrum Disorder (ASD) and developing therapies for this syndrome. Because of the lack of biomarkers of ASD, this work has been largely based on the behavioral characterization of rodent models, based on a multitude of genetic and environmental manipulations. Here we highlight how the endocannabinoid system (ECS) has recently emerged within this context of mouse behavioral studies as an etiopathological factor in ASD and a valid potential therapeutic target. We summarize the most recent results showing alterations of the ECS in rodent models of ASD, and demonstrating ASD-like behaviors in mice with altered ECS, induced either by genetic or pharmacological manipulations. We also give a critical overview of the most relevant advances in designing treatments and novel mouse models for ASD targeting the ECS, highlighting the relevance of thorough and innovative behavioral approaches to investigate the mechanisms acting underneath the complex features of ASD. © 2021 | |
| dc.description.sponsorship | Dissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes. - ANR-13-BSV4-0006 | en_US |
| dc.description.sponsorship | Représentation sensorielle lors d'états psychotiques - ANR-16-CE37-0010 | en_US |
| dc.description.sponsorship | Recepteurs aux cannabinoides dans le codage visuel cortical - ANR-18-CE16-0001 | en_US |
| dc.description.sponsorship | Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. - ANR-18-CE14-0029 | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Autism | |
| dc.subject.en | CB1r | |
| dc.subject.en | Cannabinoids | |
| dc.subject.en | Developmental disorders | |
| dc.subject.en | Mouse models | |
| dc.subject.en | Social behaviors | |
| dc.title.en | The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models | |
| dc.title.alternative | Neurosci Biobehav Rev | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.neubiorev.2021.11.031 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 34813825 | en_US |
| dc.description.sponsorshipEurope | Neurocircuitry of endocannabinoid regulation of food intake | en_US |
| dc.description.sponsorshipEurope | Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromes | en_US |
| bordeaux.journal | Neuroscience and Biobehavioral Reviews | en_US |
| bordeaux.page | 664-678 | en_US |
| bordeaux.volume | 132 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | Endocannabinoïdes et Neuroadaptation | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuroscience%20and%20Biobehavioral%20Reviews&rft.date=2022-01&rft.volume=132&rft.spage=664-678&rft.epage=664-678&rft.eissn=0149-7634&rft.issn=0149-7634&rft.au=PIETROPAOLO,%20Susanna&MARSICANO,%20Giovanni&rft.genre=article |
