PIETROPAOLO, Susanna; MARSICANO, Giovanni

doi:10.1016/j.neubiorev.2021.11.031

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

MARSICANO, Giovanni

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

Idioma

Article de revue

Este ítem está publicado en

Neuroscience and Biobehavioral Reviews. 2022-01, vol. 132, p. 664-678

Resumen en inglés

Recent years have seen an impressive amount of research devoted to understanding the etiopathology of Autism Spectrum Disorder (ASD) and developing therapies for this syndrome. Because of the lack of biomarkers of ASD, this work has been largely based on the behavioral characterization of rodent models, based on a multitude of genetic and environmental manipulations. Here we highlight how the endocannabinoid system (ECS) has recently emerged within this context of mouse behavioral studies as an etiopathological factor in ASD and a valid potential therapeutic target. We summarize the most recent results showing alterations of the ECS in rodent models of ASD, and demonstrating ASD-like behaviors in mice with altered ECS, induced either by genetic or pharmacological manipulations. We also give a critical overview of the most relevant advances in designing treatments and novel mouse models for ASD targeting the ECS, highlighting the relevance of thorough and innovative behavioral approaches to investigate the mechanisms acting underneath the complex features of ASD. © 2021< Leer menos

Palabras clave en inglés

Autism

CB1r

Cannabinoids

Developmental disorders

Mouse models

Social behaviors

URI

https://oskar-bordeaux.fr/handle/20.500.12278/171654

DOI

http://dx.doi.org/10.1016/j.neubiorev.2021.11.031

Proyecto europeo

Neurocircuitry of endocannabinoid regulation of food intake
Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromes

Proyecto ANR

Dissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes.
Représentation sensorielle lors d'états psychotiques - ANR-16-CE37-0010
Recepteurs aux cannabinoides dans le codage visuel cortical - ANR-18-CE16-0001
Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. - ANR-18-CE14-0029
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043

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The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models

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The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Proyecto europeo

Proyecto ANR

Centros de investigación