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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorPIETROPAOLO, Susanna
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
dc.date.accessioned2023-01-11T10:51:42Z
dc.date.available2023-01-11T10:51:42Z
dc.date.issued2022-01
dc.identifier.issn0149-7634en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171654
dc.description.abstractEnRecent years have seen an impressive amount of research devoted to understanding the etiopathology of Autism Spectrum Disorder (ASD) and developing therapies for this syndrome. Because of the lack of biomarkers of ASD, this work has been largely based on the behavioral characterization of rodent models, based on a multitude of genetic and environmental manipulations. Here we highlight how the endocannabinoid system (ECS) has recently emerged within this context of mouse behavioral studies as an etiopathological factor in ASD and a valid potential therapeutic target. We summarize the most recent results showing alterations of the ECS in rodent models of ASD, and demonstrating ASD-like behaviors in mice with altered ECS, induced either by genetic or pharmacological manipulations. We also give a critical overview of the most relevant advances in designing treatments and novel mouse models for ASD targeting the ECS, highlighting the relevance of thorough and innovative behavioral approaches to investigate the mechanisms acting underneath the complex features of ASD. © 2021
dc.description.sponsorshipDissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes. - ANR-13-BSV4-0006en_US
dc.description.sponsorshipReprésentation sensorielle lors d'états psychotiquesen_US
dc.description.sponsorshipRecepteurs aux cannabinoides dans le codage visuel cortical - ANR-18-CE16-0001en_US
dc.description.sponsorshipRôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. - ANR-18-CE14-0029en_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.language.isoENen_US
dc.subject.enAutism
dc.subject.enCB1r
dc.subject.enCannabinoids
dc.subject.enDevelopmental disorders
dc.subject.enMouse models
dc.subject.enSocial behaviors
dc.title.enThe role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models
dc.title.alternativeNeurosci Biobehav Reven_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neubiorev.2021.11.031en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34813825en_US
dc.description.sponsorshipEuropeNeurocircuitry of endocannabinoid regulation of food intakeen_US
dc.description.sponsorshipEuropeDevelopment of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromesen_US
bordeaux.journalNeuroscience and Biobehavioral Reviewsen_US
bordeaux.page664-678en_US
bordeaux.volume132en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuroscience%20and%20Biobehavioral%20Reviews&rft.date=2022-01&rft.volume=132&rft.spage=664-678&rft.epage=664-678&rft.eissn=0149-7634&rft.issn=0149-7634&rft.au=PIETROPAOLO,%20Susanna&MARSICANO,%20Giovanni&rft.genre=article


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