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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKOUBIYR, Ismail
dc.contributor.authorDULAU-METRAS, Cecile
dc.contributor.authorDELOIRE, Mathilde
dc.contributor.authorCHARRE-MORIN, Julie
dc.contributor.authorSAUBUSSE, Aurore
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBROCHET, Bruno
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurelie
dc.date.accessioned2023-01-03T14:22:37Z
dc.date.available2023-01-03T14:22:37Z
dc.date.issued2022-02
dc.identifier.issn0360-4012en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171596
dc.description.abstractEnTheory of mind (ToM) seems to be affected in multiple sclerosis (MS). MRI studies suggested a role of the amygdala in social cognitive performances. Therefore, we explored the role of the amygdala network in ToM using a multimodal MRI approach. In MS, patients with impaired ToM showed contradictory dysexecutive neuropsychological profile. Therefore, we compared neural networks involved in ToM and executive functions (EFs). Twenty patients with relapsing-remitting MS and 15 matched healthy controls were selected. ToM (Faux Pas test and mind stories) and EFs were assessed within and outside the scanner. All subjects underwent a battery of neuropsychological tests. Multimodal MRI with structural (diffusion imaging) and functional (resting-state and task-based) sequences was used to analyze the role and connections of the amygdala in ToM functioning. Cognitive and ToM performances were similar between patients and controls. Resting-state data revealed decreased connectivity of the left amygdala with frontal areas in patients compared to controls (p < 0.0001). During the task-based functional MRI, patients demonstrated increased connectivity between the amygdala and several cerebellar and left temporal regions (all p < 0.05). The microstructural alterations between the left amygdala and left temporal regions were associated with increased functional connectivity within the same pathway (r = 0.74; p < 0.01). No overlap was observed between functional networks involved in ToM and EFs. Our study demonstrates more connectivity recruitment between the amygdala and cerebellar and temporal regions in MS patients to reach preserved ToM performance. Microstructural abnormalities have been related to this compensatory network. Finally, different networks were involved in EFs and ToM. © 2021 Wiley Periodicals LLC.
dc.description.sponsorshipObservatoire Français de la Sclérose en Plaques - ANR-10-COHO-0002en_US
dc.language.isoENen_US
dc.subject.enAmygdala
dc.subject.enHumans
dc.subject.enMagnetic Resonance Imaging
dc.subject.enMultiple Sclerosis
dc.subject.enNeuropsychological Tests
dc.subject.enTheory of Mind
dc.subject.enRRID:SCR_009550
dc.subject.enDiffusion MRI
dc.subject.enFunctional MRI
dc.subject.enSocial cognition
dc.title.enAmygdala network reorganization mediates the theory of mind performances in multiple sclerosis
dc.title.alternativeJ Neurosci Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/jnr.24986en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34796987en_US
bordeaux.journalJournal of Neuroscience Researchen_US
bordeaux.page537-550en_US
bordeaux.volume100en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre Hospitalier Universitaire de Bordeauxen_US
hal.identifierhal-03920762
hal.version1
hal.date.transferred2023-01-03T14:22:39Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Neuroscience%20Research&amp;rft.date=2022-02&amp;rft.volume=100&amp;rft.issue=2&amp;rft.spage=537-550&amp;rft.epage=537-550&amp;rft.eissn=0360-4012&amp;rft.issn=0360-4012&amp;rft.au=KOUBIYR,%20Ismail&amp;DULAU-METRAS,%20Cecile&amp;DELOIRE,%20Mathilde&amp;CHARRE-MORIN,%20Julie&amp;SAUBUSSE,%20Aurore&amp;rft.genre=article


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