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Autoantibodies against type I IFNs in patients with critical influenza pneumonia

dc.rights.licenseopenen_US
dc.contributor.authorZHANG, Qian
dc.contributor.authorPIZZORNO, Andres
dc.contributor.authorMIORIN, Lisa
dc.contributor.authorBASTARD, Paul
dc.contributor.authorGERVAIS, Adrian
dc.contributor.authorLE VOYER, Tom
dc.contributor.authorBIZIEN, Lucy
dc.contributor.authorMANRY, Jeremy
dc.contributor.authorROSAIN, Jeremie
dc.contributor.authorPHILIPPOT, Quentin
dc.contributor.authorGOAVEC, Kelian
dc.contributor.authorPADEY, Blandine
dc.contributor.authorCUPIC, Anastasija
dc.contributor.authorLAURENT, Emilie
dc.contributor.authorSAKER, Kahina
dc.contributor.authorVANKER, Martti
dc.contributor.authorSAREKANNU, Karita
dc.contributor.authorGARCIA-SALUM, Tamara
dc.contributor.authorFERRES, Marcela
dc.contributor.authorLE CORRE, Nicole
dc.contributor.authorSANCHEZ-CESPEDES, Javier
dc.contributor.authorBALSERA-MANZANERO, Maria
dc.contributor.authorCARRATALA, Jordi
dc.contributor.authorRETAMAR-GENTIL, Pilar
dc.contributor.authorABELENDA-ALONSO, Gabriela
dc.contributor.authorVALIENTE, Adoracion
dc.contributor.authorTIBERGHIEN, Pierre
dc.contributor.authorZINS, Marie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorMEYTS, Isabelle
dc.contributor.authorHAERYNCK, Filomeen
dc.contributor.authorCASTAGNOLI, Riccardo
dc.contributor.authorNOTARANGELO, Luigi D.
dc.contributor.authorGONZALEZ-GRANADO, Luis I.
dc.contributor.authorDOMINGUEZ-PINILLA, Nerea
dc.contributor.authorANDREAKOS, Evangelos
dc.contributor.authorTRIANTAFYLLIA, Vasiliki
dc.contributor.authorRODRIGUEZ-GALLEGO, Carlos
dc.contributor.authorSOLE-VIOLAN, Jordi
dc.contributor.authorRUIZ-HERNANDEZ, Jose Juan
dc.contributor.authorRODRIGUEZ DE CASTRO, Felipe
dc.contributor.authorFERRERES, Jose
dc.contributor.authorBRIONES, Marisa
dc.contributor.authorWAUTERS, Joost
dc.contributor.authorVANDERBEKE, Lore
dc.contributor.authorFEYS, Simon
dc.contributor.authorKUO, Chen-Yen
dc.contributor.authorLEI, Wei-Te
dc.contributor.authorKU, Cheng-Lung
dc.contributor.authorTAL, Galit
dc.contributor.authorETZIONI, Amos
dc.contributor.authorHANNA, Suhair
dc.contributor.authorFOURNET, Thomas
dc.contributor.authorCASALEGNO, Jean-Sebastien
dc.contributor.authorQUEROMES, Gregory
dc.contributor.authorARGAUD, Laurent
dc.contributor.authorJAVOUHEY, Etienne
dc.contributor.authorROSA-CALATRAVA, Manuel
dc.contributor.authorCORDERO, Elisa
dc.contributor.authorAYDILLO, Teresa
dc.contributor.authorMEDINA, Rafael A.
dc.contributor.authorKISAND, Kai
dc.contributor.authorPUEL, Anne
dc.contributor.authorJOUANGUY, Emmanuelle
dc.contributor.authorABEL, Laurent
dc.contributor.authorCOBAT, Aurelie
dc.contributor.authorTROUILLET-ASSANT, Sophie
dc.contributor.authorGARCIA-SASTRE, Adolfo
dc.contributor.authorCASANOVA, Jean-Laurent
dc.date.accessioned2022-12-16T14:57:45Z
dc.date.available2022-12-16T14:57:45Z
dc.date.issued2022-11-07
dc.identifier.issn1540-9538 (Electronic) 0022-1007 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171566
dc.description.abstractEnAutoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-α2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-ω. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 × 10-5), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-α2 and IFN-ω (OR = 11.7, P = 1.3 × 10-5), especially those <70 yr old (OR = 139.9, P = 3.1 × 10-10). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for ∼5% of cases of life-threatening influenza pneumonia in patients <70 yr old.
dc.description.sponsorshipInstitut Hospitalo-Universitaire Imagineen_US
dc.description.sponsorshipIntegrative Biology of Emerging Infectious Diseasesen_US
dc.description.sponsorshipCovid-19 and interferons: from discovery to therapyen_US
dc.description.sponsorshipAnalyse multi-omique de l'immunité anti-virale: de l'identification des circuits biologiques pertinents à la découverte de défauts monogéniques héréditaires de l'immunité chez les patients avec infections virales sévèresen_US
dc.description.sponsorshipRecherche des Déficits immunitaires innées monogéniques prédisposant au syndrome inflammatoire multisystémique chez l'enfant.en_US
dc.description.sponsorshipBases génétiques et immunologiques des auto-anticorps contre les interférons de type I prédisposant aux formes sévères de COVID-19.en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enAutoantibodies against type I IFNs in patients with critical influenza pneumonia
dc.title.alternativeJ Exp Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1084/jem.20220514en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36112363en_US
bordeaux.journalJournal of Experimental Medicineen_US
bordeaux.volume219en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Experimental%20Medicine&amp;rft.date=2022-11-07&amp;rft.volume=219&amp;rft.issue=11&amp;rft.eissn=1540-9538%20(Electronic)%200022-1007%20(Linking)&amp;rft.issn=1540-9538%20(Electronic)%200022-1007%20(Linking)&amp;rft.au=ZHANG,%20Qian&amp;PIZZORNO,%20Andres&amp;MIORIN,%20Lisa&amp;BASTARD,%20Paul&amp;GERVAIS,%20Adrian&amp;rft.genre=article


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