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Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

dc.rights.licenseopenen_US
dc.contributor.authorMAUSCHITZ, Matthias M.
dc.contributor.authorVERZIJDEN, Timo
dc.contributor.authorSCHUSTER, Alexander K.
dc.contributor.authorELBAZ, Hisham
dc.contributor.authorPFEIFFER, Norbert
dc.contributor.authorKHAWAJA, Anthony
dc.contributor.authorLUBEN, Robert N.
dc.contributor.authorFOSTER, Paul J.
dc.contributor.authorRAUSCHER, Franziska G.
dc.contributor.authorWIRKNER, Kerstin
dc.contributor.authorKIRSTEN, Toralf
dc.contributor.authorJONAS, Jost B.
dc.contributor.authorBIKBOV, Mukharram M.
dc.contributor.authorHOGG, Ruth
dc.contributor.authorPETO, Tunde
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUGNARD-GREGOIRE, Audrey
dc.contributor.authorBERTELSEN, Geir
dc.contributor.authorERKE, Maja Gran
dc.contributor.authorTOPOUZIS, Fotis
dc.contributor.authorGIANNOULIS, Dimitrios A.
dc.contributor.authorBRANDL, Caroline
dc.contributor.authorHEID, Iris M.
dc.contributor.authorCREUZOT-GARCHER, Catherine P.
dc.contributor.authorGABRIELLE, Pierre-Henry
dc.contributor.authorHENSE, Hans-Werner
dc.contributor.authorPAULEIKHOFF, Daniel
dc.contributor.authorBARRETO, Patricia
dc.contributor.authorCOIMBRA, Rita
dc.contributor.authorPIERMAROCCHI, Stefano
dc.contributor.authorDAIEN, Vincent
dc.contributor.authorHOLZ, Frank G.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
dc.contributor.authorFINGER, Robert P.
dc.date.accessioned2022-12-16T13:44:13Z
dc.date.available2022-12-16T13:44:13Z
dc.date.issued2022-11-07
dc.identifier.issn1468-2079 (Electronic) 0007-1161 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171550
dc.description.abstractEnBACKGROUND/AIMS: To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. METHODS: We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. RESULTS: Between studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. CONCLUSION: Our study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.title.enAssociation of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans
dc.title.alternativeBr J Ophthalmolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/bjo-2022-321985en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36344262en_US
bordeaux.journalBritish Journal of Ophthalmologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British%20Journal%20of%20Ophthalmology&rft.date=2022-11-07&rft.eissn=1468-2079%20(Electronic)%200007-1161%20(Linking)&rft.issn=1468-2079%20(Electronic)%200007-1161%20(Linking)&rft.au=MAUSCHITZ,%20Matthias%20M.&VERZIJDEN,%20Timo&SCHUSTER,%20Alexander%20K.&ELBAZ,%20Hisham&PFEIFFER,%20Norbert&rft.genre=article


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