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dc.rights.licenseopenen_US
dc.contributor.authorAMADOU, Amina
dc.contributor.authorPRAUD, Delphine
dc.contributor.authorCOUDON, Thomas
dc.contributor.authorDEYGAS, Floriane
dc.contributor.authorGRASSOT, Leny
dc.contributor.authorDUBUIS, Mathieu
dc.contributor.authorFAURE, Elodie
dc.contributor.authorCOUVIDAT, Florian
dc.contributor.authorCAUDEVILLE, Julien
dc.contributor.authorBESSAGNET, Bertrand
dc.contributor.authorSALIZZONI, Pietro
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
dc.contributor.authorGULLIVER, John
dc.contributor.authorSEVERI, Gianluca
dc.contributor.authorMANCINI, Francesca Romana
dc.contributor.authorFERVERS, Beatrice
dc.date.accessioned2022-12-14T09:55:54Z
dc.date.available2022-12-14T09:55:54Z
dc.date.issued2023-01-15
dc.identifier.issn1873-6424 (Electronic) 0269-7491 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170632
dc.description.abstractEnNitrogen dioxide (NO(2)) is an important air pollutant due to its adverse effects on human health. Yet, current evidence on the association between NO(2) and the risk of breast cancer lacks consistency. In this study, we investigated the association between long-term exposure to NO(2) and breast cancer risk in the French E3N cohort study. Association of breast cancer risk with NO(2) exposure was assessed in a nested case-control study within the French E3N cohort including 5222 breast cancer cases identified over the 1990-2011 follow-up period and 5222 matched controls. Annual mean concentrations of NO(2) at participants' residential addresses for each year from recruitment 1990 through 2011, were estimated using a land use regression (LUR) model. Multivariable conditional logistic regression models were used to compute odds ratios (ORs) and their 95% confidence intervals (CIs). Additional analyses were performed using NO(2) concentrations estimated by CHIMERE, a chemistry transport model. Overall, the mean NO(2) exposure was associated with an increased risk of breast cancer. In all women, for each interquartile range (IQR) increase in NO(2) levels (LUR: 17.8 μg/m(3)), the OR of the model adjusted for confounders was 1.09 (95% CI: 1.01-1.18). The corresponding OR in the fully adjusted model (additionally adjusted for established breast cancer risk factors) was 1.07 (95% CI: 0.98-1.15). By menopausal status, results for postmenopausal women were comparable to those for all women, while no association was observed among premenopausal women. By hormone receptor status, the OR of estrogen receptor positive breast cancer = 1.07 (95% CI: 0.97-1.19) in the fully adjusted model. Additional analyses using the CHIMERE model showed slight differences in ORs estimates. The results of this study indicate an increased risk of breast cancer associated with long-term exposure to NO(2) air pollution. Observing comparable effects of NO(2) exposure estimated by two different models, reinforces these findings.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAir pollution
dc.subject.enNitrogen dioxide
dc.subject.enBreast cancer
dc.subject.enResidential addresses
dc.subject.enMenopausal status
dc.subject.enHormone receptor status
dc.title.enLong-term exposure to nitrogen dioxide air pollution and breast cancer risk: A nested case-control within the French E3N cohort study
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envpol.2022.120719en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36435283en_US
bordeaux.journalEnvironmental Pollutionen_US
bordeaux.page120719en_US
bordeaux.volume317en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDLigue Contre le Canceren_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDInstitut Gustave-Roussyen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Pollution&rft.date=2023-01-15&rft.volume=317&rft.spage=120719&rft.epage=120719&rft.eissn=1873-6424%20(Electronic)%200269-7491%20(Linking)&rft.issn=1873-6424%20(Electronic)%200269-7491%20(Linking)&rft.au=AMADOU,%20Amina&PRAUD,%20Delphine&COUDON,%20Thomas&DEYGAS,%20Floriane&GRASSOT,%20Leny&rft.genre=article


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