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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDUMETZ, Fabien
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorGINIEIS, Rachel
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBURE, Corinne
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARIE, Anais
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorALFOS, Serge
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPALLET, Veronique
ORCID: 0000-0002-9078-3269
IDREF: 066841763
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X
IDREF: 156530244
dc.date.accessioned2022-12-07T14:23:12Z
dc.date.available2022-12-07T14:23:12Z
dc.date.issued2020-09-12
dc.identifier.issn1028-415Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170497
dc.description.abstractEnVitamin A (retinol) and related retinoids are micronutrients provided by food. Retinol derivatives are growth factors important for development, cell differentiation and tissue homeostasis, especially in the brain. Objective: The hippocampus is a pivotal brain structure for learning and memory and hippocampal-dependent memory is highly sensitive to retinoids action. However, the underlying mechanisms are still unclear. In this study, we characterized the impact of vitamin A deficiency on memory and neuronal plasticity, focusing on the CA1 region of the hippocampus in rats. Methods: Weaned male Wistar rats were fed a control (5 UI/g) or deficient vitamin A diet (0 UI/g) for 10 weeks. The effect of vitamin A supplementation (20 UI/g) for 3 weeks was also tested. Memory performances were assessed in the Y-maze (n = 24–30/group), retinoic acid levels were measured (LC-MS/MS) in the serum and in the hippocampus (n = 5/group), CA1 neuronal architecture was analyzed with Golgi staining (n = 17–20 neurons/group) and electrophysiological patch-clamp recordings were performed on hippocampal brain slices (n = 6–11/group). Results: Vitamin A deficiency from weaning significantly lowered hippocampal levels of retinoic acid, reduced dendritic length and branching of CA1 pyramidal neurons and decreased spontaneous glutamatergic synaptic events and synaptic plasticity. When replenishment with moderate dose of dietary vitamin A for 3 weeks was done, most of the synaptic and morphological alterations were absent. Conclusion: This study provides new mechanistic insight to understand the critical role of retinoic acid in hippocampal function. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enVitamin A
dc.subject.enRetinoic acid
dc.subject.enHippocampus
dc.subject.enmemory
dc.subject.enNeuron morphology
dc.subject.ensynaptic network
dc.title.enNeuronal morphology and synaptic plasticity in the hippocampus of vitamin A deficient rats
dc.typeArticle de revueen_US
dc.identifier.doi10.1080/1028415X.2020.1809877en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32924835en_US
bordeaux.journalNutritional Neuroscienceen_US
bordeaux.page779-790en_US
bordeaux.volume25en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDSociété Française de Nutritionen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutritional%20Neuroscience&rft.date=2020-09-12&rft.volume=25&rft.issue=4&rft.spage=779-790&rft.epage=779-790&rft.eissn=1028-415X&rft.issn=1028-415X&rft.au=DUMETZ,%20Fabien&GINIEIS,%20Rachel&BURE,%20Corinne&MARIE,%20Anais&ALFOS,%20Serge&rft.genre=article


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