| dc.rights.license | open | en_US |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | ROUMES, Hélène | |
| hal.structure.identifier | Université de Lausanne = University of Lausanne [UNIL] | |
| dc.contributor.author | JOLLÉ, Charlotte | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BLANC, Jordy | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| hal.structure.identifier | Laboratoire commun Imagerie Métabolique Multi-Noyaux Multi-Organes [I3M] | |
| dc.contributor.author | BENKHALED, Imad | |
| hal.structure.identifier | Universidade Federal do Rio Grande do Sul [Porto Alegre] [UFRGS] | |
| dc.contributor.author | CHATAIN, Carolina Piletti | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | MASSOT, Philippe | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | RAFFARD, Gérard | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BOUCHAUD, Véronique | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BIRAN, Marc | |
| hal.structure.identifier | Université de Lausanne = University of Lausanne [UNIL] | |
| dc.contributor.author | PYTHOUD, Catherine | |
| hal.structure.identifier | Université de Lausanne = University of Lausanne [UNIL] | |
| dc.contributor.author | DÉGLON, Nicole | |
| hal.structure.identifier | Universidade Federal do Rio Grande do Sul [Porto Alegre] [UFRGS] | |
| dc.contributor.author | ZIMMER, Eduardo | |
| hal.structure.identifier | Université de Lausanne = University of Lausanne [UNIL] | |
| hal.structure.identifier | Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques [U 1082] [ IRTOMIT [Poitiers]] | |
| dc.contributor.author | PELLERIN, Luc | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BOUZIER-SORE, Anne-Karine | |
| dc.date.accessioned | 2022-11-24T14:43:56Z | |
| dc.date.available | 2022-11-24T14:43:56Z | |
| dc.date.issued | 2021-11-23 | |
| dc.identifier.issn | 0027-8424 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170383 | |
| dc.description.abstractEn | Significance For decades, it was claimed that glucose was the sole and sufficient energy substrate to sustain neuronal activity and brain function. Our results challenge this view by demonstrating that despite glucose availability, lactate shuttling from astrocytes to neurons via monocarboxylate transporters is necessary to give rise to the blood oxygen level-dependent signal (used as a surrogate marker for activation) in the rat cerebral cortex following whisker stimulation. Moreover, lactate shuttling turned out to be also essential for sustaining behavioral performance associated with activation of the rat barrel cortex. These findings call for a reappraisal of neuroenergetics and the role of astrocytes in determining brain activation and function. | |
| dc.description.sponsorship | Exploration in vivo du couplage métabolique entre neurones et astrocytes lors de l'activation cérébrale: étude par spectroscopie de RMN - ANR-15-CE37-0012 | en_US |
| dc.description.sponsorship | Initiative d'excellence de l'Université de Bordeaux | en_US |
| dc.description.sponsorship | Translational Research and Advanced Imaging Laboratory | en_US |
| dc.language.iso | EN | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/ | |
| dc.subject.en | Brain metabolism | |
| dc.subject.en | Monocarboxylate transporter | |
| dc.subject.en | fMRI | |
| dc.subject.en | MRS | |
| dc.subject.en | Learning and memory | |
| dc.title.en | Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1073/pnas.2112466118 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| bordeaux.journal | Proceedings of the National Academy of Sciences of the United States of America | en_US |
| bordeaux.volume | 118 | en_US |
| bordeaux.hal.laboratories | Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536 | en_US |
| bordeaux.issue | 47 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03826912 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20of%20the%20United%20States%20of%20America&rft.date=2021-11-23&rft.volume=118&rft.issue=47&rft.eissn=0027-8424&rft.issn=0027-8424&rft.au=ROUMES,%20H%C3%A9l%C3%A8ne&JOLL%C3%89,%20Charlotte&BLANC,%20Jordy&BENKHALED,%20Imad&CHATAIN,%20Carolina%20Piletti&rft.genre=article | |
