Locoregional treatments for digital ulcers in systemic sclerosis: A systematic review
| dc.rights.license | open | en_US |
| dc.contributor.author | COSTEDOAT, Ingrid | |
| dc.contributor.author | MASSON, Maeva | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | DUFFAU, Pierre | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | LAZARO, Estibaliz | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | RICHEZ, Christophe | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | TRUCHETET, Marie Elise | |
| dc.date.accessioned | 2022-11-15T11:04:02Z | |
| dc.date.available | 2022-11-15T11:04:02Z | |
| dc.date.issued | 2021-05-27 | |
| dc.identifier.issn | 0001-5555 (Print) 1651-2057 (Online) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170263 | |
| dc.description.abstractEn | The management of digital ulcers in systemic sclerosis is difficult. While the 2017 European League Against Rheumatism (EULAR) guidelines clearly defined the use of systemic therapies for digital ulcers, little is known about the efficacy of locoregional treatments. The aim of this review is to systematically assess the spectrum of published locoregional therapies for digital ulcers. A total of 58 studies were included. Among the different locoregional treatment strategies descri-bed, injections of fat-derived cells and botulinum toxin showed promising results in the reduction of pain and the number of digital ulcers. By contrast, this review found that sympathectomy yielded disappointing re-sults, with low rates of effectiveness and frequent recurrence. For other treatments, such as hyperbaric oxygen therapy, phototherapy (ultraviolet A), low-level light therapy, intermittent compression, Waon therapy, extracorporeal shockwave, vitamin E gel, and topical dimethyl sulphoxide, the conflicting results or limited published data reflected the low level of evi-dence. Larger randomized clinical trials are required to confirm the validity of promising techniques. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
| dc.subject.en | Botulinum toxin | |
| dc.subject.en | Digital ulcers | |
| dc.subject.en | Fat-derived cells | |
| dc.subject.en | Systematic re-view | |
| dc.subject.en | Systemic sclerosis | |
| dc.title.en | Locoregional treatments for digital ulcers in systemic sclerosis: A systematic review | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.2340/00015555-3839 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 34043013 | en_US |
| bordeaux.journal | Acta Dermato-Venereologica | en_US |
| bordeaux.volume | 101 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03962542 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-01-30T10:40:45Z | |
| hal.export | true | |
| dc.rights.cc | CC BY-NC | en_US |
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