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dc.rights.licenseopenen_US
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorPUPIER, Emilie
dc.contributor.authorSANTOS, Alicia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorETCHAMENDY, Nicole
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorLAVIELLE, Aurelie
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorFERRIERE, Amandine
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARIGHETTO, Aline
dc.contributor.authorRESMINI, Eugenia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOTA, Daniela
dc.contributor.authorWEBB, Susan M.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTABARIN, Antoine
dc.date.accessioned2022-11-09T10:56:30Z
dc.date.available2022-11-09T10:56:30Z
dc.date.issued2022-08-08
dc.identifier.issn1664-2392en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170240
dc.description.abstractEnContext: Impaired cognition and altered quality of life (QoL) may persist despite long-term remission of Cushing’s disease (CD). Persistent comorbidities and treatment modalities may account for cognitive impairments. Therefore, the role of hypercortisolism per se on cognitive sequelae remains debatable. Objective: To investigate whether memory and QoL are impaired after long-term remission of CD in patients with no confounding comorbidity. Design and Setting: Cross-sectional case-control study in two tertiary referral centers Patients: 25 patients (44.5 ± 2.4 years) in remission from CD for 102.7 ± 19.3 Mo and 25 well-matched controls, without comorbidity or treatment liable to impair cognition. Main Outcome Measure(s): Hippocampus- and prefrontal cortex-dependent memory, including memory flexibility and working memory, were investigated using multiple tests including sensitive locally-developed computerized tasks. Depression and anxiety were evaluated with the MADRS and HADS questionnaires. QoL was evaluated with the SF-36 and CushingQoL questionnaires. The intensity of CD was assessed using mean urinary free cortisol and a score for clinical symptoms. Results: CD patients displayed similar performance to controls in all cognitive tests. In contrast, despite the absence of depression and a minimal residual clinical Cushing score, patients had worse QoL. Most of the SF36 subscales and the CushingQoL score were negatively associated only with the duration of exposure to hypercortisolism (p≤ 0.01 to 0.001). Conclusions: Persistent comorbidities can be a primary cause of long-lasting cognitive impairment and should be actively treated. Persistently altered QoL may reflect irreversible effects of hypercortisolism, highlighting the need to reduce its duration. Clinical Trial Registration number: https://clinicaltrials.gov, identifier NCT02603653. Copyright © 2022 Pupier, Santos, Etchamendy, Lavielle, Ferriere, Marighetto, Resmini, Cota, Webb and Tabarin.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHemoglobin A1c
dc.subject.enHydrocortisone
dc.subject.enAdrenal Insufficiency
dc.subject.enAdult
dc.subject.enAnxiety
dc.subject.enArticle
dc.subject.enBody Mass
dc.subject.enCognition
dc.subject.enCognitive Defect
dc.subject.enComorbidity
dc.subject.enControlled Study
dc.subject.enCross-Sectional Study
dc.subject.enCushing Disease
dc.subject.enDexamethasone Suppression Test
dc.subject.enDiastolic Blood Pressure
dc.subject.enEcchymosis
dc.subject.enFemale
dc.subject.enHippocampus
dc.subject.enHospital Anxiety And Depression Scale
dc.subject.enHuman
dc.subject.enHypercortisolism
dc.subject.enHypertension
dc.subject.enHypothyroidism
dc.subject.enMajor Clinical Study
dc.subject.enMale
dc.subject.enMontgomery Asberg Depression Rating Scale
dc.subject.enNeuropsychological Test
dc.subject.enObesity
dc.subject.enQuality Of Life
dc.subject.enRey Auditory Verbal Learning Test
dc.subject.enRey Osterrieth Complex Figure Test
dc.subject.enShort Form 36
dc.subject.enSystolic Blood Pressure
dc.subject.enTertiary Care Center
dc.subject.enVisual Memory
dc.subject.enWechsler Memory Scale
dc.subject.enWorking Memory
dc.title.enImpaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission
dc.title.alternativeFront Endocrinol.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fendo.2022.934347en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36004342en_US
bordeaux.journalFrontiers in Endocrinologyen_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie de la mémoire déclarativeen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03845130
hal.version1
hal.date.transferred2022-11-09T10:56:38Z
hal.exporttrue
dc.rights.ccCC BYen_US
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