COUPE, Pierrick; MANJON, Jose V.; MANSENCAL, Boris; TOURDIAS, Thomas; CATHELINE, Gwenaelle; PLANCHE, Vincent

doi:10.1002/hbm.25850

MANJON, Jose V.
ITACA
Universitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia [UPV]

MANSENCAL, Boris

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Article de revue

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Human Brain Mapping. 2022-07, vol. 43, n° 10, p. 3270-3282

Resumen en inglés

In this article, we present an innovative MRI-based method for Alzheimer disease (AD) detection and mild cognitive impairment (MCI) prognostic, using lifespan trajectories of brain structures. After a full screening of the most discriminant structures between AD and normal aging based on MRI volumetric analysis of 3,032 subjects, we propose a novel Hippocampal-Amygdalo-Ventricular Atrophy score (HAVAs) based on normative lifespan models and AD lifespan models. During a validation on three external datasets on 1,039 subjects, our approach showed very accurate detection (AUC ≥ 94%) of patients with AD compared to control subjects and accurate discrimination (AUC = 78%) between progressive MCI and stable MCI (during a 3-year follow-up). Compared to normative modeling, classical machine learning methods and recent state-of-the-art deep learning methods, our method demonstrated better classification performance. Moreover, HAVAs simplicity makes it fully understandable and thus well-suited for clinical practice or future pharmaceutical trials.< Leer menos

Palabras clave en inglés

Alzheimer Disease

Atrophy

Cognitive Dysfunction

Disease Progression

Hippocampus

Humans

Longevity

Magnetic Resonance Imaging

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170092

DOI

http://dx.doi.org/10.1002/hbm.25850

Proyecto ANR

Apprentissage profond pour la volumétrie cérébrale : vers le BigData en neuroscience - ANR-18-CE45-0013
Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057
Initiative d'excellence de l'Université de Bordeaux

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Hippocampal-amygdalo-ventricular atrophy score: Alzheimer disease detection using normative and pathological lifespan models.

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Hippocampal-amygdalo-ventricular atrophy score: Alzheimer disease detection using normative and pathological lifespan models.

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