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Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years' Evolution Data on a 71-Patient Series

dc.rights.licenseopenen_US
dc.contributor.authorTREFOND, Ludovic
dc.contributor.authorFRANCES, Camille
dc.contributor.authorCOSTEDOAT-CHALUMEAU, Nathalie
dc.contributor.authorPIETTE, Jean-Charles
dc.contributor.authorHAROCHE, Julien
dc.contributor.authorSAILLER, Laurent
dc.contributor.authorASSAAD, Souad
dc.contributor.authorVIALLARD, Jean-Francois
dc.contributor.authorJEGO, Patrick
dc.contributor.authorHOT, Arnaud
dc.contributor.authorCONNAULT, Jerome
dc.contributor.authorGALEMPOIX, Jean-Marc
dc.contributor.authorASLANGUL, Elisabeth
dc.contributor.authorLIMAL, Nicolas
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorFAGUER, Stanislas
dc.contributor.authorCHOSIDOW, Olivier
dc.contributor.authorDELIGNY, Christophe
dc.contributor.authorLIFERMANN, Francois
dc.contributor.authorMARIA, Alexandre Thibault Jacques
dc.contributor.authorPEREIRA, Bruno
dc.contributor.authorAUMAITRE, Olivier
dc.contributor.authorANDRE, Marc
dc.contributor.authorABSCESSES, On Behalf Of The French Study Group On Aseptic
dc.date.accessioned2022-10-19T10:30:33Z
dc.date.available2022-10-19T10:30:33Z
dc.date.issued2022-06-25
dc.identifier.issn2077-0383 (Print) 2077-0383 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170073
dc.description.abstractEnAseptic abscess (AA) syndrome is a rare type of inflammatory disorder involving polymorphonuclear neutrophils (PMNs), often associated with inflammatory bowel disease (IBD). This study sought to describe the clinical characteristics and evolution of this syndrome in a large cohort. We included all patients included in the French AA syndrome register from 1999 to 2020. All patients fulfilled the criteria outlined by Andre et al. in 2007. Seventy-one patients were included, 37 of which were men (52.1%), of a mean age of 34.5 +/- 17 years. The abscesses were located in the spleen (71.8%), lymph nodes (50.7%), skin (29.5%), liver (28.1%), lung (22.5), and rarer locations (brain, genitals, kidneys, ENT, muscles, or breasts). Of all the patients, 59% presented with an associated disease, primarily IBD (42%). They were treated with colchicine (28.1%), corticosteroids (85.9%), immunosuppressants (61.9%), and biologics (32.3%). A relapse was observed in 62% of cases, mostly in the same organ. Upon multivariate analysis, factors associated with the risk of relapse were: prescription of colchicine (HR 0.52; 95% CI [0.28-0.97]; p = 0.042), associated IBD (HR 0.57; 95% CI [0.32-0.99]; p = 0.047), and hepatic or skin abscesses at diagnosis (HR 2.14; 95% CI [1.35-3.40]; p = 0.001 and HR 1.78; 95% CI [1.07-2.93]; p = 0.024, respectively). No deaths occurred related to this disease. This large retrospective cohort study with long follow up showed that AA syndrome is a relapsing systemic disease that can evolve on its own or be the precursor of an underlying disease, such as IBD. Of all the available treatments, colchicine appeared to be protective against relapse.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAseptic abscess syndrome
dc.subject.enCrohn’s disease
dc.subject.enColchicine
dc.subject.enBiologics
dc.title.enAseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years' Evolution Data on a 71-Patient Series
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/jcm11133669en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35806955en_US
bordeaux.journalJournal of Clinical Medicineen_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue13en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03763425
hal.version1
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Medicine&rft.date=2022-06-25&rft.volume=11&rft.issue=13&rft.eissn=2077-0383%20(Print)%202077-0383%20(Linking)&rft.issn=2077-0383%20(Print)%202077-0383%20(Linking)&rft.au=TREFOND,%20Ludovic&FRANCES,%20Camille&COSTEDOAT-CHALUMEAU,%20Nathalie&PIETTE,%20Jean-Charles&HAROCHE,%20Julien&rft.genre=article


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