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Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study

dc.rights.licenseopenen_US
dc.contributor.authorDU PREEZ, Andrea
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFEVRE ARBOGAST, Sophie
dc.contributor.authorGONZALEZ-DOMINGUEZ, Raul
dc.contributor.authorHOUGHTON, Vikki
dc.contributor.authorDE LUCIA, Chiara
dc.contributor.authorLOW, Dorrain Y.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST-LIMA, Cecile
dc.contributor.authorPALLAS, Merce
dc.contributor.authorSANCHEZ-PLA, Alex
dc.contributor.authorURPI-SARDA, Mireia
dc.contributor.authorRUIGROK, Silvie R.
dc.contributor.authorALTENDORFER, Barbara
dc.contributor.authorAIGNER, Ludwig
dc.contributor.authorLUCASSEN, Paul J.
dc.contributor.authorKOROSI, Aniko
dc.contributor.authorMANACH, Claudine
dc.contributor.authorANDRES-LACUEVA, Cristina
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorTHURET, Sandrine
dc.date.accessioned2022-10-17T12:32:42Z
dc.date.available2022-10-17T12:32:42Z
dc.date.issued2022-07-07
dc.identifier.issn1476-5578 (Electronic) 1359-4184 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170038
dc.description.abstractEnEnvironmental factors like diet have been linked to depression and/or relapse risk in later life. This could be partially driven by the food metabolome, which communicates with the brain via the circulatory system and interacts with hippocampal neurogenesis (HN), a form of brain plasticity implicated in depression aetiology. Despite the associations between HN, diet and depression, human data further substantiating this hypothesis are largely missing. Here, we used an in vitro model of HN to test the effects of serum samples from a longitudinal ageing cohort of 373 participants, with or without depressive symptomology. 1% participant serum was applied to human fetal hippocampal progenitor cells, and changes in HN markers were related to the occurrence of depressive symptoms across a 12-year period. Key nutritional, metabolomic and lipidomic biomarkers (extracted from participant plasma and serum) were subsequently tested for their ability to modulate HN. In our assay, we found that reduced cell death and increased neuronal differentiation were associated with later life depressive symptomatology. Additionally, we found impairments in neuronal cell morphology in cells treated with serum from participants experiencing recurrent depressive symptoms across the 12-year period. Interestingly, we found that increased neuronal differentiation was modulated by increased serum levels of metabolite butyrylcarnitine and decreased glycerophospholipid, PC35:1(16:0/19:1), levels - both of which are closely linked to diet - all in the context of depressive symptomology. These findings potentially suggest that diet and altered HN could subsequently shape the trajectory of late-life depressive symptomology.
dc.description.sponsorshipUniversity of Bordeaux Graduate School in Digital Public Health - ANR-17-EURE-0019en_US
dc.description.sponsorshipCOGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enImpaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41380-022-01644-1en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35794184en_US
bordeaux.journalMolecular Psychiatryen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDConseil régional de Bourgogne-Franche-Comtéen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
hal.identifierhal-03817763
hal.version1
hal.date.transferred2022-10-17T12:32:48Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20Psychiatry&rft.date=2022-07-07&rft.eissn=1476-5578%20(Electronic)%201359-4184%20(Linking)&rft.issn=1476-5578%20(Electronic)%201359-4184%20(Linking)&rft.au=DU%20PREEZ,%20Andrea&LEFEVRE%20ARBOGAST,%20Sophie&GONZALEZ-DOMINGUEZ,%20Raul&HOUGHTON,%20Vikki&DE%20LUCIA,%20Chiara&rft.genre=article


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