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Self-Assembly of Bilayer Vesicles Made of Saturated Long Chain Fatty Acids

hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorDOULIEZ, Jean-Paul
hal.structure.identifierUnité de recherche sur les Biopolymères, Interactions Assemblages [BIA]
dc.contributor.authorHOUINSOU-HOUSSOU, Bérénice
hal.structure.identifierUnité de recherche sur les Biopolymères, Interactions Assemblages [BIA]
dc.contributor.authorFAMEAU, Anne-Laure
hal.structure.identifierCentre de Recherche Paul Pascal [CRPP]
dc.contributor.authorNAVAILLES, Laurence
hal.structure.identifierCentre de Recherche Paul Pascal [CRPP]
dc.contributor.authorNALLET, Frédéric
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGRÉLARD, Axelle
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDUFOURC, Erick J.
hal.structure.identifierUnité de recherche sur les Biopolymères, Interactions Assemblages [BIA]
dc.contributor.authorGAILLARD, Cedric
dc.date.issued2016
dc.identifier.issn0743-7463
dc.description.abstractEnSaturated long chain fatty acids (sLCFA, e.g., C14:0, C16:0, and C18:0) are potentially the greenest and cheapest surfactants naturally available. However, because aqueous sodium soaps of sLCFA are known to crystallize, the self-assembly of stable bilayer vesicles has not been reported yet. Here, by using such soaps in combination with guanidine hydrochloride (GuHCl), which has been shown recently to prevent crystallization, we were capable of producing stable bilayer vesicles made of sLCFA. The phase diagrams were established for a variety of systems showing that vesicles can form in a broad range of composition and pH. Both solid state NMR and small-angle neutron scattering allowed demonstrating that in such vesicles sLCFA are arranged in a bilayer structure which exhibits similar dynamic and structural properties as those of phospholipid membranes. We expect these vesicles to be of interest as model systems of protocells and minimal cells but also for various applications since fatty acids are potentially substitutes to phospholipids, synthetic surfactants, and polymers.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.title.enSelf-Assembly of Bilayer Vesicles Made of Saturated Long Chain Fatty Acids
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.langmuir.5b03627
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalLangmuir
bordeaux.pagepp. 401-410
bordeaux.volume32
bordeaux.issue2
bordeaux.peerReviewedoui
hal.identifierhal-01368857
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01368857v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Langmuir&rft.date=2016&rft.volume=32&rft.issue=2&rft.spage=pp.%20401-410&rft.epage=pp.%20401-410&rft.eissn=0743-7463&rft.issn=0743-7463&rft.au=DOULIEZ,%20Jean-Paul&HOUINSOU-HOUSSOU,%20B%C3%A9r%C3%A9nice&FAMEAU,%20Anne-Laure&NAVAILLES,%20Laurence&NALLET,%20Fr%C3%A9d%C3%A9ric&rft.genre=article


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