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Comparative Transcriptome Analysis Shows Conserved Metabolic Regulation during Production of Secondary Metabolites in Filamentous Fungi.

hal.structure.identifierDepartment of Biology and Biological Engineering
dc.contributor.authorNIELSEN, Jens Christian
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierDepartment of Biology and Biological Engineering
dc.contributor.authorPRIGENT, Sylvain
hal.structure.identifierDepartment of Biotechnology and Biomedicine
dc.contributor.authorGRIJSEELS, Sietske
hal.structure.identifierDepartment of Biotechnology and Biomedicine
dc.contributor.authorWORKMAN, Mhairi
hal.structure.identifierDepartment of Biology and Biological Engineering
dc.contributor.authorJI, Boyang
hal.structure.identifierDepartment of Biology and Biological Engineering
hal.structure.identifierNovo Nordisk Foundation Center for Biosustainability
dc.contributor.authorNIELSEN, Jens
dc.date.issued2019
dc.identifier.issn2379-5077
dc.description.abstractEnSecondary metabolites are a major source of pharmaceuticals, especially antibiotics. However, the development of efficient processes of production of secondary metabolites has proved troublesome due to a limited understanding of the metabolic regulations governing secondary metabolism. By analyzing the conservation in gene expression across secondary metabolite-producing fungal species, we identified a metabolic signature that links primary and secondary metabolism and that demonstrates that fungal metabolism is tailored for the efficient production of secondary metabolites. The insight that we provide can be used to develop high-yielding fungal cell factories that are optimized for the production of specific secondary metabolites of pharmaceutical interest.
dc.language.isoen
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subjectcell factories
dc.subjectcomparative transcriptomics
dc.subjectfilamentous fungi
dc.subject.ensecondary metabolism
dc.title.enComparative Transcriptome Analysis Shows Conserved Metabolic Regulation during Production of Secondary Metabolites in Filamentous Fungi.
dc.typeArticle de revue
dc.identifier.doi10.1128/mSystems.00012-19
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
bordeaux.journalmSystems
bordeaux.pagee00012-19
bordeaux.volume4
bordeaux.issue2
bordeaux.peerReviewedoui
hal.identifierhal-02622105
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02622105v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=mSystems&rft.date=2019&rft.volume=4&rft.issue=2&rft.spage=e00012-19&rft.epage=e00012-19&rft.eissn=2379-5077&rft.issn=2379-5077&rft.au=NIELSEN,%20Jens%20Christian&PRIGENT,%20Sylvain&GRIJSEELS,%20Sietske&WORKMAN,%20Mhairi&JI,%20Boyang&rft.genre=article


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