Comparative Transcriptome Analysis Shows Conserved Metabolic Regulation during Production of Secondary Metabolites in Filamentous Fungi.
PRIGENT, Sylvain
Biologie du fruit et pathologie [BFP]
Department of Biology and Biological Engineering
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Biologie du fruit et pathologie [BFP]
Department of Biology and Biological Engineering
PRIGENT, Sylvain
Biologie du fruit et pathologie [BFP]
Department of Biology and Biological Engineering
Biologie du fruit et pathologie [BFP]
Department of Biology and Biological Engineering
NIELSEN, Jens
Department of Biology and Biological Engineering
Novo Nordisk Foundation Center for Biosustainability
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Department of Biology and Biological Engineering
Novo Nordisk Foundation Center for Biosustainability
Idioma
en
Article de revue
Este ítem está publicado en
mSystems. 2019, vol. 4, n° 2, p. e00012-19
Resumen en inglés
Secondary metabolites are a major source of pharmaceuticals, especially antibiotics. However, the development of efficient processes of production of secondary metabolites has proved troublesome due to a limited understanding ...Leer más >
Secondary metabolites are a major source of pharmaceuticals, especially antibiotics. However, the development of efficient processes of production of secondary metabolites has proved troublesome due to a limited understanding of the metabolic regulations governing secondary metabolism. By analyzing the conservation in gene expression across secondary metabolite-producing fungal species, we identified a metabolic signature that links primary and secondary metabolism and that demonstrates that fungal metabolism is tailored for the efficient production of secondary metabolites. The insight that we provide can be used to develop high-yielding fungal cell factories that are optimized for the production of specific secondary metabolites of pharmaceutical interest.< Leer menos
Palabras clave
cell factories
comparative transcriptomics
filamentous fungi
Palabras clave en inglés
secondary metabolism
Orígen
Importado de HalCentros de investigación