NIELSEN, Jens Christian; PRIGENT, Sylvain; GRIJSEELS, Sietske; WORKMAN, Mhairi; JI, Boyang; NIELSEN, Jens

doi:10.1128/mSystems.00012-19

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NIELSEN, Jens Christian
Department of Biology and Biological Engineering

PRIGENT, Sylvain
Biologie du fruit et pathologie [BFP]
Department of Biology and Biological Engineering

GRIJSEELS, Sietske
Department of Biotechnology and Biomedicine

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Article de revue

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mSystems. 2019, vol. 4, n° 2, p. e00012-19

Résumé en anglais

Secondary metabolites are a major source of pharmaceuticals, especially antibiotics. However, the development of efficient processes of production of secondary metabolites has proved troublesome due to a limited understanding of the metabolic regulations governing secondary metabolism. By analyzing the conservation in gene expression across secondary metabolite-producing fungal species, we identified a metabolic signature that links primary and secondary metabolism and that demonstrates that fungal metabolism is tailored for the efficient production of secondary metabolites. The insight that we provide can be used to develop high-yielding fungal cell factories that are optimized for the production of specific secondary metabolites of pharmaceutical interest.< Réduire

Mots clés

cell factories

comparative transcriptomics

filamentous fungi

Mots clés en anglais

secondary metabolism