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Characterization of GMO or glyphosate effects on the composition of maize grain and maize-based diet for rat feeding

hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBERNILLON, Stéphane
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorMAUCOURT, Mickael
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorDEBORDE, Catherine
hal.structure.identifierUnité de recherche Mycologie et Sécurité des Aliments [MycSA]
dc.contributor.authorCHÉREAU, Sylvain
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorJACOB, Daniel
hal.structure.identifierPrévention et promotion de la cancérogénèse par les aliments [ToxAlim-PPCA]
dc.contributor.authorPRIYMENKO, Nathalie
hal.structure.identifierToxAlim [ToxAlim]
dc.contributor.authorLAPORTE, Bérengère
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
dc.contributor.authorCOUMOUL, Xavier
hal.structure.identifierToxAlim [ToxAlim]
dc.contributor.authorSALLES, Bernard
hal.structure.identifierReproduction et développement des plantes [RDP]
dc.contributor.authorROGOWSKY, Peter
hal.structure.identifierUnité de recherche Mycologie et Sécurité des Aliments [MycSA]
dc.contributor.authorRICHARD-FORGET, Florence
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorMOING, Annick
dc.date.issued2018
dc.identifier.issn1573-3882
dc.description.abstractEn<strong>Introduction</strong> In addition to classical targeted biochemical analyses, metabolomic analyses seem pertinent to reveal expected as well as unexpected compositional differences between plant genetically modified organisms (GMO) and non-GMO samples. Data previously published in the existing literature led to divergent conclusions on the effect of maize transgenes on grain compositional changes and feeding effects. Therefore, a new study examining field-grown harvested products and feeds derived from them remains useful. <strong>Objectives</strong> Our aim was to use a metabolomics approach to characterize grain and grain-based diet compositional changes for two GMO events, one involving Bacillus thuringiensis toxin to provide insect resistance and the other one conferring herbicide tolerance by detoxification of glyphosate. We also investigated the potential compositional modifications induced by the use of a glyphosate-based herbicide on the transgenic line conferring glyphosate tolerance. <strong>Results</strong> The majority of statistically significant differences in grain composition, evidenced by the use of 1H-NMR profiling of polar extracts and LC-ESI-QTOF-MS profiling of semi-polar extracts, could be attributed to the combined effect of genotype and environment. In comparison, transgene and glyphosate effects remained limited in grain for the compound families studied. Some but not all compositional changes observed in grain were also detected in grain-based diets formulated for rats. <strong>Conclusion</strong> Only part of the data previously published in the existing literature on maize grains of plants with the same GMO events could be reproduced in our experiment. All spectra have been deposited in a repository freely accessible to the public. Our grain and diet characterization opened the way for an in depth study of the effects of these diets on rat health.
dc.description.sponsorshipDéveloppement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation - ANR-11-INBS-0010
dc.description.sponsorshipCentre français de phénomique végétale - ANR-11-INBS-0012
dc.language.isoen
dc.publisherSpringer Verlag
dc.subjectMetabolomics
dc.subjectGrain
dc.subject.enMaize
dc.subject.enGMO
dc.subject.enRat diet
dc.title.enCharacterization of GMO or glyphosate effects on the composition of maize grain and maize-based diet for rat feeding
dc.typeArticle de revue
dc.identifier.doi10.1007/s11306-018-1329-9
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Médecine vétérinaire et santé animal
bordeaux.journalMetabolomics
bordeaux.page1-12
bordeaux.volume14
bordeaux.issue36
bordeaux.peerReviewedoui
hal.identifierhal-02624451
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02624451v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Metabolomics&amp;rft.date=2018&amp;rft.volume=14&amp;rft.issue=36&amp;rft.spage=1-12&amp;rft.epage=1-12&amp;rft.eissn=1573-3882&amp;rft.issn=1573-3882&amp;rft.au=BERNILLON,%20St%C3%A9phane&amp;MAUCOURT,%20Mickael&amp;DEBORDE,%20Catherine&amp;CH%C3%89REAU,%20Sylvain&amp;JACOB,%20Daniel&amp;rft.genre=article


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