Finding and identifying the viral needle in the metagenomic haystack: Trends and Challenges
SOUEIDAN, Hayssam
Biothérapies des maladies génétiques et cancers
Centre de Bioinformatique de Bordeaux [CBIB]
Biothérapies des maladies génétiques et cancers
Centre de Bioinformatique de Bordeaux [CBIB]
SCHMITT, Louise-Amélie
Centre de Bioinformatique de Bordeaux [CBIB]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Leer más >
Centre de Bioinformatique de Bordeaux [CBIB]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
SOUEIDAN, Hayssam
Biothérapies des maladies génétiques et cancers
Centre de Bioinformatique de Bordeaux [CBIB]
Biothérapies des maladies génétiques et cancers
Centre de Bioinformatique de Bordeaux [CBIB]
SCHMITT, Louise-Amélie
Centre de Bioinformatique de Bordeaux [CBIB]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Centre de Bioinformatique de Bordeaux [CBIB]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
NIKOLSKI, Macha
Centre de Bioinformatique de Bordeaux [CBIB]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
< Leer menos
Centre de Bioinformatique de Bordeaux [CBIB]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Idioma
en
Article de revue
Este ítem está publicado en
Frontiers in Microbiology. 2014-12-05, vol. 5, p. 5:739
Frontiers Media
Resumen en inglés
Collectively, viruses have the greatest genetic diversity on Earth, occupy extremely varied niches and are likely able to infect all living organisms. Viral infections are an important issue for human health and cause ...Leer más >
Collectively, viruses have the greatest genetic diversity on Earth, occupy extremely varied niches and are likely able to infect all living organisms. Viral infections are an important issue for human health and cause considerable economic losses when agriculturally important crops or husbandry animals are infected. The advent of metagenomics has provided a precious tool to study viruses by sampling them in natural environments and identifying the genomic composition of a sample. However, reaching a clear recognition and taxonomic assignment of the identified viruses has been hampered by the computational difficulty of these problems. In this perspective paper we examine the trends in current research for the identification of viral sequences in a metagenomic sample, pinpoint the intrinsic computational difficulties for the identification of novel viral sequences within metagenomic samples, and suggest possible avenues to overcome them.< Leer menos
Palabras clave en inglés
Taxonomic assignment
host-pathogen interactions
NGS
virome
microbial metagenomics
Orígen
Importado de HalCentros de investigación