Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in <em>Arabidopsis</em>
hal.structure.identifier | Gregor Mendel Institute of Molecular Plant Biology [GMI] | |
dc.contributor.author | DAL SANTO, Sylvia | |
hal.structure.identifier | Gregor Mendel Institute of Molecular Plant Biology [GMI] | |
dc.contributor.author | STAMPFL, Hansjörg | |
hal.structure.identifier | Gregor Mendel Institute of Molecular Plant Biology [GMI] | |
dc.contributor.author | KRASENSKY, Julia | |
hal.structure.identifier | Gregor Mendel Institute of Molecular Plant Biology [GMI] | |
dc.contributor.author | KEMPA, Stefan | |
hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
dc.contributor.author | GIBON, Yves | |
hal.structure.identifier | Gregor Mendel Institute of Molecular Plant Biology [GMI] | |
dc.contributor.author | PETUTSCHNIG, Elena | |
hal.structure.identifier | Gregor Mendel Institute of Molecular Plant Biology [GMI] | |
dc.contributor.author | ROZHON, Wilfried | |
hal.structure.identifier | Research Institute of Molecular Pathology [IMP] | |
dc.contributor.author | HEUCK, Alexander | |
hal.structure.identifier | Research Institute of Molecular Pathology [IMP] | |
dc.contributor.author | CLAUSEN, Tim | |
hal.structure.identifier | Gregor Mendel Institute of Molecular Plant Biology [GMI] | |
dc.contributor.author | JONAK, Claudia | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1040-4651 | |
dc.description.abstractEn | Diverse stresses such as high salt conditions cause an increase in reactive oxygen species (ROS), necessitating a redox stress response. However, little is known about the signaling pathways that regulate the antioxidant system to counteract oxidative stress. Here, we show that a Glycogen Synthase Kinase3 from Arabidopsis thaliana (ASK alpha) regulates stress tolerance by activating Glc-6-phosphate dehydrogenase (G6PD), which is essential for maintaining the cellular redox balance. Loss of stress-activated ASK alpha leads to reduced G6PD activity, elevated levels of ROS, and enhanced sensitivity to salt stress. Conversely, plants overexpressing ASK alpha have increased G6PD activity and low levels of ROS in response to stress and are more tolerant to salt stress. ASK alpha stimulates the activity of a specific cytosolic G6PD isoform by phosphorylating the evolutionarily conserved Thr-467, which is implicated in cosubstrate binding. Our results reveal a novel mechanism of G6PD adaptive regulation that is critical for the cellular stress response. | |
dc.language.iso | en | |
dc.publisher | American Society of Plant Biologists (ASPB) | |
dc.title.en | Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in <em>Arabidopsis</em> | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1105/tpc.112.101279 | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biologie végétale | |
bordeaux.journal | The Plant cell | |
bordeaux.page | 3380-3392 | |
bordeaux.volume | 24 | |
bordeaux.issue | 8 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-02647870 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-02647870v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Plant%20cell&rft.date=2012&rft.volume=24&rft.issue=8&rft.spage=3380-3392&rft.epage=3380-3392&rft.eissn=1040-4651&rft.issn=1040-4651&rft.au=DAL%20SANTO,%20Sylvia&STAMPFL,%20Hansj%C3%B6rg&KRASENSKY,%20Julia&KEMPA,%20Stefan&GIBON,%20Yves&rft.genre=article |
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