Metabolic network reconstruction and their topological analysis
Langue
en
Chapitre d'ouvrage
Ce document a été publié dans
Plant Metabolic Flux Analysis : Methods and Protocols, Plant Metabolic Flux Analysis : Methods and Protocols. 2014, vol. 1090
Springer Science+Business Media
Résumé en anglais
This chapter focuses on the way to build a metabolic network and how to analyze its structure. The first part of this chapter describes the methods of the network model reconstruction from biochemical data found in specialized ...Lire la suite >
This chapter focuses on the way to build a metabolic network and how to analyze its structure. The first part of this chapter describes the methods of the network model reconstruction from biochemical data found in specialized databases and/or literature. The second part deals with metabolic pathway analysis as a useful tool for better understanding the complex architecture of intracellular metabolism. The graph analysis and the stoichiometric network analysis are important approaches for understanding the network topology and consequently the function of metabolic networks. Among the methods presented, the Elementary Flux Modes analysis will be more detailed. Finally, we illustrate in this chapter an example of network reconstruction from heterotrophic plant cells metabolism and its topological analysis leading to a huge number of Elementary Flux Modes.< Réduire
Mots clés
plant cell metabolism
Mots clés en anglais
metabolic network
metabolic pathway analysis
stoichiometry matrix
topological analysis
elementary flux modes
Origine
Importé de halUnités de recherche