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All-optical broadband ultrasonography of single cells.

hal.structure.identifierInstitut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.contributor.authorDEHOUX, Thomas
hal.structure.identifierInstitut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.contributor.authorABI GHANEM, Maroun
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorZOUANI, Omar El-Farouk
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorRAMPNOUX, Jean-Michel
hal.structure.identifierInstitut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.contributor.authorGUILLET, Yannick
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorDILHAIRE, Stefan
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDURRIEU, Marie-Christine
hal.structure.identifierInstitut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.contributor.authorAUDOIN, Bertrand
dc.date.created2014-10-23
dc.date.issued2015-03-03
dc.identifier.issn2045-2322
dc.description.abstractEnCell mechanics play a key role in several fundamental biological processes, such as migration, proliferation, differentiation and tissue morphogenesis. In addition, many diseased conditions of the cell are correlated with altered cell mechanics, as in the case of cancer progression. For this there is much interest in methods that can map mechanical properties with a sub-cell resolution. Here, we demonstrate an inverted pulsed opto-acoustic microscope (iPOM) that operates in the 10 to 100 GHz range. These frequencies allow mapping quantitatively cell structures as thin as 10 nm and resolving the fibrillar details of cells. Using this non-invasive all-optical system, we produce high-resolution images based on mechanical properties as the contrast mechanisms, and we can observe the stiffness and adhesion of single migrating stem cells. The technique should allow transferring the diagnostic and imaging abilities of ultrasonic imaging to the single-cell scale, thus opening new avenues for cell biology and biomaterial sciences.
dc.description.sponsorshipImagerie quantitative par acoustique picoseconde de l'adhésion de cellules individuelles sur biomatériaux - ANR-13-BS09-0021
dc.language.isoen
dc.publisherNature Publishing Group
dc.subject.enBiosensors
dc.subject.enCellular Imaging
dc.title.enAll-optical broadband ultrasonography of single cells.
dc.typeArticle de revue
dc.identifier.doi10.1038/srep08650
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
dc.subject.halPhysique [physics]/Physique [physics]/Optique [physics.optics]
bordeaux.journalScientific Reports
bordeaux.page8650 (1-5)
bordeaux.volume5
bordeaux.peerReviewedoui
hal.identifierhal-01140140
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01140140v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2015-03-03&rft.volume=5&rft.spage=8650%20(1-5)&rft.epage=8650%20(1-5)&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=DEHOUX,%20Thomas&ABI%20GHANEM,%20Maroun&ZOUANI,%20Omar%20El-Farouk&RAMPNOUX,%20Jean-Michel&GUILLET,%20Yannick&rft.genre=article


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