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Comparative Multifractal Analysis of Dynamic Infrared Thermograms and X-Ray Mammograms Enlightens Changes in the Environment of Malignant Tumors

hal.structure.identifierLaboratory of Physical Foundation of Strength
dc.contributor.authorGERASIMOVA-CHECHKINA, Evgeniya
hal.structure.identifierCompuMAINE Laboratory, Department of Mathematics and Statics
dc.contributor.authorTONER, Brian
hal.structure.identifierCompuMAINE Laboratory, Department of Mathematics and Statics
dc.contributor.authorMARIN, Zach
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorAUDIT, Benjamin
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorROUX, Stephane
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorARGOUL, Françoise
hal.structure.identifierCompuMAINE Laboratory, Department of Mathematics and Statics
dc.contributor.authorKHALIL, Andre
hal.structure.identifierDepartment of Therapeutic and Propedeutic Dentistry
dc.contributor.authorGILEVA, Olga
hal.structure.identifierLaboratory of Physical Foundation of Strength
dc.contributor.authorNAIMARK, Oleg
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorARNEODO, Alain
dc.date.created2016-06-06
dc.date.issued2016-08-09
dc.identifier.issn1664-042X
dc.description.abstractEnThere is growing evidence that the microenvironment surrounding a tumor plays a special role in cancer development and cancer therapeutic resistance. Tumors arise from the dysregulation and alteration of both the malignant cells and their environment. By providing tumor-repressing signals, the microenvironment can impose and sustain normal tissue architecture. Once tissue homeostasis is lost, the altered microenvironment can create a niche favoring the tumorigenic transformation process. A major challenge in early breast cancer diagnosis is thus to show that these physiological and architectural alterations can be detected with currently used screening techniques. In a recent study, we used a 1D wavelet-based multi-scale method to analyze breast skin temperature temporal fluctuations collected with an IR thermography camera in patients with breast cancer. This study reveals that the multifractal complexity of temperature fluctuations superimposed on cardiogenic and vasomotor perfusion oscillations observed in healthy breasts is lost in malignant tumor foci in cancerous breasts. Here we use a 2D wavelet-based multifractal method to analyze the spatial fluctuations of breast density in the X-ray mammograms of the same panel of patients. As compared to the long-range correlations and anti-correlations in roughness fluctuations, respectively observed in dense and fatty breast areas, some significant change in the nature of breast density fluctuations with some clear loss of correlations is detected in the neighborhood of malignant tumors. This attests to some architectural disorganization that may deeply affect heat transfer and related thermomechanics in breast tissues, corroborating the change to homogeneous monofractal temperature fluctuations recorded in cancerous breasts with the IR camera. These results open new perspectives in computer-aided methods to assist in early breast cancer diagnosis.
dc.language.isoen
dc.publisherFrontiers
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enbreast cancer
dc.subject.endynamic IR thermograms
dc.subject.enX-ray mammograms
dc.subject.enmultifractal analysis
dc.subject.enwavelet transform modulus maxima method
dc.title.enComparative Multifractal Analysis of Dynamic Infrared Thermograms and X-Ray Mammograms Enlightens Changes in the Environment of Malignant Tumors
dc.typeArticle de revue
dc.identifier.doi10.3389/fphys.2016.00336
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalFrontiers in Physiology
bordeaux.page336 (1-15)
bordeaux.volume7
bordeaux.peerReviewedoui
hal.identifierhal-01391739
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01391739v1
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