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Single metallic nanoparticle imaging for protein detection in cells

hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorCOGNET, Laurent
hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorTARDIN, Catherine
hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorBOYER, David
hal.structure.identifierPhysiologie cellulaire de la synapse [PCS]
dc.contributor.authorCHOQUET, Daniel
hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorTAMARAT, Philippe
hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorLOUNIS, Brahim
dc.date.issued2003-09-30
dc.identifier.issn0027-8424
dc.description.abstractEnWe performed a visualization of membrane proteins labeled with 10-nm gold nanoparticles in cells, using an all-optical method based on photothermal interference contrast. The high sensitivity of the method and the stability of the signals allows 3D imaging of individual nanoparticles without the drawbacks of photobleaching and blinking inherent to fluorescent markers. A simple analytical model is derived to account for the measurements of the signal amplitude and the spatial resolution. The photothermal interference contrast method provides an efficient, reproducible, and promising way to visualize low amounts of proteins in cells by optical means.
dc.language.isoen
dc.publisherNational Academy of Sciences
dc.subject.ensingle molecule detection
dc.subject.engold nanoparticle
dc.subject.enphotothermal
dc.title.enSingle metallic nanoparticle imaging for protein detection in cells
dc.typeArticle de revue
dc.identifier.doi10.1073/pnas.1534635100
dc.subject.halPhysique [physics]/Physique [physics]/Optique [physics.optics]
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
dc.identifier.arxiv0704.3816
bordeaux.journalProceedings of the National Academy of Sciences of the United States of America
bordeaux.page11350
bordeaux.volume100
bordeaux.issue20
bordeaux.peerReviewedoui
hal.identifierhal-00143959
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00143959v1
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