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hal.structure.identifierLaboratoire Physico-Chimie Industrielle du Médicament [LPCIM]
dc.contributor.authorCORVIS, Yohann
hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorNÉGRIER, Philippe
hal.structure.identifierLaboratoire Physico-Chimie Industrielle du Médicament [LPCIM]
dc.contributor.authorLAZERGES, Mathieu
hal.structure.identifierLaboratoire de Pharmacochimie
dc.contributor.authorMASSIP, Stéphane
hal.structure.identifierLaboratoire de Pharmacochimie
dc.contributor.authorLÉGER, Jean-Michel
hal.structure.identifierLaboratoire Physico-Chimie Industrielle du Médicament [LPCIM]
dc.contributor.authorESPEAU, Philippe
dc.date.created2009-11-30
dc.date.issued2010
dc.identifier.issn1520-6106
dc.description.abstractEnWe present the synthesis, structure determination, and thermodynamic properties of a never reported cocrystal prepared with lidocaine and L-menthol. The temperature-composition phase diagram of the lidocaine/L-menthol binary system was achieved using differential scanning calorimetry and X-ray diffraction experiments. The present study demonstrates that the only way to perform a phase equilibrium survey of the lidocaine/L-menthol system is to prepare the binary mixtures from the cocrystal, an equimolar stoichiometric compound of L-menthol and lidocaine. We describe a process that is crucial to elaborate pharmaceutical agents that remain in their thermodynamical stable state throughout their preparation, manufacture, and storage for effective use.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/
dc.title.enLidocaine/L-Menthol Binary System: Cocrystallization versus Solid-State Immiscibility
dc.typeArticle de revue
dc.identifier.doi10.1021/jp101303j
dc.subject.halChimie/Cristallographie
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacie galénique
bordeaux.journalJournal of Physical Chemistry B
bordeaux.page5420–5426
bordeaux.volume114
bordeaux.issue16
bordeaux.peerReviewedoui
hal.identifierhal-00505411
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00505411v1
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