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hal.structure.identifierNeuro-anatomie fonctionnelle du comportement et de ses troubles
dc.contributor.authorSCHMIDT, Liane
hal.structure.identifierNeuro-anatomie fonctionnelle du comportement et de ses troubles
dc.contributor.authorD'ARC, Baudouin Forgeot
hal.structure.identifierUnité de Recherche en Sciences Cognitives et Affectives [URECA]
dc.contributor.authorLAFARGUE, Gilles
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorGALANAUD, Damien
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorCZERNECKI, Virginie
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorGRABLI, David
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorSCHÜPBACH, Michael W M
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorHARTMANN, Andreas
hal.structure.identifierNeuro-anatomie fonctionnelle du comportement et de ses troubles
dc.contributor.authorLÉVY, Richard
hal.structure.identifierNeuro-anatomie fonctionnelle du comportement et de ses troubles
dc.contributor.authorDUBOIS, Bruno
hal.structure.identifierNeuro-anatomie fonctionnelle du comportement et de ses troubles
dc.contributor.authorPESSIGLIONE, Mathias
dc.date.issued2008-05
dc.identifier.issn0006-8950
dc.description.abstractEnBilateral basal ganglia lesions have been reported to induce a particular form of apathy, termed auto-activation deficit (AAD), principally defined as a loss of self-driven behaviour that is reversible with external stimulation. We hypothesized that AAD reflects a dysfunction of incentive motivation, a process that translates an expected reward (or goal) into behavioural activation. To investigate this hypothesis, we designed a behavioural paradigm contrasting an instructed (externally driven) task, in which subjects have to produce different levels of force by squeezing a hand grip, to an incentive (self-driven) task, in which subjects can win, depending on their hand grip force, different amounts of money. Skin conductance was simultaneously measured to index affective evaluation of monetary incentives. Thirteen AAD patients with bilateral striato-pallidal lesions were compared to thirteen unmedicated patients with Parkinson's; disease (PD), which is characterized by striatal dopamine depletion and regularly associated with apathy. AAD patients did not differ from PD patients in terms of grip force response to external instructions or skin conductance response to monetary incentives. However, unlike PD patients, they failed to distinguish between monetary incentives in their grip force. We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards.
dc.language.isoen
dc.publisherOxford University Press
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshSeverity of Illness Index
dc.subject.meshAged, 80 and over
dc.subject.meshBasal Ganglia
dc.subject.meshBasal Ganglia Diseases
dc.subject.meshBrain Mapping
dc.subject.meshFemale
dc.subject.meshGalvanic Skin Response
dc.subject.meshHand Strength
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMotivation
dc.subject.meshParkinson Disease
dc.subject.meshPsychomotor Disorders
dc.subject.meshPsychomotor Performance
dc.subject.meshReward
dc.title.enDisconnecting force from money : effects of basal ganglia damage on incentive motivation
dc.typeArticle de revue
dc.identifier.doi10.1093/brain/awn045
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
bordeaux.journalBrain - A Journal of Neurology
bordeaux.page1303-1310
bordeaux.volume131
bordeaux.issue5
bordeaux.peerReviewedoui
hal.identifierhal-00333398
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00333398v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain%20-%20A%20Journal%20of%20Neurology&rft.date=2008-05&rft.volume=131&rft.issue=5&rft.spage=1303-1310&rft.epage=1303-1310&rft.eissn=0006-8950&rft.issn=0006-8950&rft.au=SCHMIDT,%20Liane&D'ARC,%20Baudouin%20Forgeot&LAFARGUE,%20Gilles&GALANAUD,%20Damien&CZERNECKI,%20Virginie&rft.genre=article


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