The influence of mutation on protein-ligand docking optimization: a locality analysis
TALBI, El-Ghazali
Parallel Cooperative Multi-criteria Optimization [DOLPHIN]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
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Parallel Cooperative Multi-criteria Optimization [DOLPHIN]
Laboratoire d'Informatique Fondamentale de Lille [LIFL]
Language
en
Communication dans un congrès
This item was published in
2008-09-13, Dortmund. 2008, vol. 5199, p. 589-598
Springer
English Abstract
Evolutionary approaches to protein-ligand docking typically use a real-value encoding and mutation operators based on Gaussian and Cauchy distributions. The choice of mutation is important for an efficient algorithm for ...Read more >
Evolutionary approaches to protein-ligand docking typically use a real-value encoding and mutation operators based on Gaussian and Cauchy distributions. The choice of mutation is important for an efficient algorithm for this problem.We investigate the effect of mutation operators by locality analysis. High locality means that small variations in the genotype imply small variations in the phenotype. Results show that Gaussian-based operators have stronger locality than Cauchy-based ones, especially if an annealing scheme is used to control the variance.Read less <
Origin
Hal imported