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Theoretical investigation of the efficacy of antiangiogenic drugs combined to chemotherapy in xenografted mice.

hal.structure.identifierNumerical Medicine [NUMED]
dc.contributor.authorLIGNET, Floriane
hal.structure.identifierCenter of Cancer and Systems Biology [CCSB]
dc.contributor.authorBENZEKRY, Sébastien
hal.structure.identifierNumerical Medicine [NUMED]
dc.contributor.authorWILSON, Shelby
hal.structure.identifierEvaluation et modélisation des effets thérapeutiques [LBBE]
dc.contributor.authorBILLY, Frédérique
hal.structure.identifierModélisation, contrôle et calcul [MC2]
dc.contributor.authorSAUT, Olivier
hal.structure.identifierCentre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
dc.contributor.authorTOD, Michel
hal.structure.identifierCentre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
dc.contributor.authorYOU, Benoit
hal.structure.identifierÉcole nationale vétérinaire d'Alfort [ENVA]
dc.contributor.authorADDA BERKANE, A.
hal.structure.identifierÉcole nationale vétérinaire d'Alfort [ENVA]
dc.contributor.authorKASSOUR, S.
hal.structure.identifierÉcole nationale vétérinaire d'Alfort [ENVA]
dc.contributor.authorWEI, M. X.
hal.structure.identifierNumerical Medicine [NUMED]
dc.contributor.authorGRENIER, Emmanuel
hal.structure.identifierNumerical Medicine [NUMED]
dc.contributor.authorRIBBA, Benjamin
dc.date.issued2013-03-07
dc.identifier.issn0022-5193
dc.description.abstractEnAntiangiogenic drugs were developed with the aim to inhibit the formation of intratumoral blood vessels and in consequence the growth of solid tumors. As these drugs are generally combined with classical cytotoxic drugs in the treatment of cancer patients, finding the optimal combinations remains a complex challenge due to possible interactions of the antiangiogenic compound with the hemodynamic property of the treated tumor. To analyze this problem, we developed a multi-scale model of vascular tumor growth combining a molecular model of VEGF signaling pathways and a tissue model of the tumor expansion including the dynamics of cellular and tissue processes of tumor growth and response to treatments. We addressed the potential impact of antiangiogenic drug by defining a new index of vasculature quality which depends on the balance between stable and unstable vessels within the tumor mass. Our goal was to investigate the interactions between a chemotherapy and a antiangiogenic treatment, and, by simulating the model, to identify the optimal delay of chemotherapy delivery after the administration of the antiangiogenic compound. This theoretical analysis could be used in the future to optimize antiangiogenic drug delivery in preclinical settings and to facilitate the translation from preclinical to clinical studies.
dc.language.isoen
dc.publisherElsevier
dc.title.enTheoretical investigation of the efficacy of antiangiogenic drugs combined to chemotherapy in xenografted mice.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jtbi.2012.12.013
dc.subject.halInformatique [cs]/Modélisation et simulation
bordeaux.journalJournal of Theoretical Biology
bordeaux.page86-99
bordeaux.volume320
bordeaux.peerReviewedoui
hal.identifierhal-00785876
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00785876v1
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