Show simple item record

hal.structure.identifierCenter of Cancer and Systems Biology [CCSB]
hal.structure.identifierModélisation, contrôle et calcul [MC2]
dc.contributor.authorBENZEKRY, Sébastien
hal.structure.identifierCentre de Recherches en Oncologie biologique et Oncopharmacologie [CRO2]
dc.contributor.authorBARBOLOSI, Dominique
hal.structure.identifierLaboratoire d'Analyse, Topologie, Probabilités [LATP]
dc.contributor.authorBENABDALLAH, Assia
hal.structure.identifierLaboratoire d'Analyse, Topologie, Probabilités [LATP]
dc.contributor.authorHUBERT, Florence
hal.structure.identifierCenter of Cancer and Systems Biology [CCSB]
dc.contributor.authorHAHNFELDT, Philip
dc.date.created2012-11-09
dc.description.abstractEnA mathematical model for time development of metastases and their distribution in size and carrying capacity is presented. The model is used to theoretically investigate anti-cancer therapies such as surgery and chemical treatments (cytotoxic or anti-angiogenic), in monotherapy or in combination. Quantification of the effect of surgery on the size distribution of metastatic colonies is derived. For systemic therapies, emphasis is placed on the differences between the treatment of an isolated lesion and a population of metastases. Combination therapy is addressed, in particular the problem of the drugs administration sequence. Theoretical optimal schedules are derived that show the superiority of a metronomic administration scheme (defined as a continuous administration of a given amount of drug spread during the whole therapeutic cycle) on a classical Maximum Tolerated Dose scheme (where the dose is given as a few concentrated administrations at the beginning of the cycle), for the total metastatic burden in the organism.
dc.language.isoen
dc.subject.enMetastases
dc.subject.enMathematical modeling
dc.subject.enAnti-cancer therapy
dc.subject.enAnti-angiogenesis
dc.subject.enMetronomics
dc.title.enQuantitative Analysis of the Tumor/Metastasis System and its Optimal Therapeutic Control
dc.typeDocument de travail - Pré-publication
dc.subject.halMathématiques [math]/Equations aux dérivées partielles [math.AP]
dc.subject.halSciences du Vivant [q-bio]/Cancer
dc.identifier.arxiv1306.4840
hal.identifierhal-00836023
hal.version1
hal.audienceNon spécifiée
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00836023v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=BENZEKRY,%20S%C3%A9bastien&BARBOLOSI,%20Dominique&BENABDALLAH,%20Assia&HUBERT,%20Florence&HAHNFELDT,%20Philip&rft.genre=preprint


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record