OCTEAU, Vivien; COGNET, Laurent; DUCHESNE, Laurence; LASNE, David; SCHAEFFER, Nicolas; FERNIG, David G.; LOUNIS, Brahim

doi:10.1021/nn800771m

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OCTEAU, Vivien
Centre de physique moléculaire optique et hertzienne [CPMOH]

COGNET, Laurent
Centre de physique moléculaire optique et hertzienne [CPMOH]

DUCHESNE, Laurence
Centre for Nanoscale Science

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ACS Nano. 2009-02-24, vol. 3, n° 2, p. 345-350

American Chemical Society

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Fluorescence correlation spectroscopy (FCS) is a popular technique, complementary to cell imaging for the investigation of dynamic processes in living cells. Based on fluorescence, this single molecule method suffers from artifacts originating from the poor fluorophore photophysics: photobleaching, blinking, and saturation. To circumvent these limitations we present here a new correlation method called photothermal absorption correlation spectroscopy (PhACS) which relies on the absorption properties of tiny nano-objects. PhACS is based on the photothermal heterodyne detection technique and measures akin FCS, the time correlation function of the detected signals. Application of this technique to the precise determination of the hydrodynamic sizes of different functionalized gold nanoparticles are presented, highlighting the potential of this method.< Leer menos

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photothermal detection

correlation spectroscopy

single molecule

gold nanoparticles

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Photothermal Absorption Correlation Spectroscopy

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