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dc.rights.licenseopenen_US
dc.contributor.authorMA, Xiangui
dc.contributor.authorGAO, Wenyue
dc.contributor.authorDU, Fangxin
dc.contributor.authorYUAN, Fan
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorYU, Jing
dc.contributor.authorGUAN, Yiran
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorSOJIC, Neso
dc.contributor.authorXU, Guobao
dc.date.accessioned2022-10-12T14:27:00Z
dc.date.available2022-10-12T14:27:00Z
dc.date.issued2021-07-20
dc.identifier.issn0001-4842en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/158446
dc.description.abstractEnConspectusElectrochemiluminescence (ECL) is a light-emitting process which combines the intriguing merits of both electrochemical and chemiluminescent methods. It is an extensively used method especially in clinical analysis and biological research due to its high sensitivity, wide dynamic range, and good reliability. ECL devices are critical for the development and applications of ECL. Much effort has been expended to improve the sensitivity, portability, affordability, and throughput of new ECL devices, which allow ECL to adapt broad usage scenarios.In this Account, we summarize our efforts on the recent development of ECL devices including new electrodes, ECL devices based on a wireless power transfer (WPT) technique, and novel bipolar electrochemistry. As the essential components in the ECL devices, electrodes play an important role in ECL detection. We have significantly improved the sensitivity of luminol ECL detection of H2O2 by using a stainless steel electrode. By using semiconductor materials (e.g., silicon and BiVO4), we have exploited photoinduced ECL to generate intense emission at much lower potentials upon illumination. For convenience, portability, and disposability, ECL devices based on cheap WPT devices have been designed. A small diode has been employed to rectify alternating current into direct current to dramatically enhance ECL intensity, enabling sensitive ECL detection using a smart phone as a detector. Finally, we have developed several ECL devices based on bipolar electrochemistry in view of the convenience of multiplex ECL sensing using a bipolar electrode (BPE). On the basis of the wireless feature of BPE, we have employed movable BPEs (e.g., BPE swimmers and magnetic rotating BPE) for deep exploration of the motional and ECL properties of dynamic BPE systems. To make full use of the ECL solution, we have dispersed numerous micro-/nano-BPEs in solution to produce intense 3D ECL in the entire solution, instead of 2D ECL in conventional ECL devices. In addition, the interference of ECL noise from driving electrodes was minimized by introducing the stainless steel with a passivation layer as the driving electrode. To eliminate the need for the fabrication of electrode arrays and the interference from the driving electrode and to decrease the applied voltage, we develop a new-type BPE device consisting of a single-electrode electrochemical system (SEES) based on a resistance-induced potential difference. The SEES is fabricated easily by attaching a multiperforated plate to a single film electrode. It enables the simultaneous detection of many samples and analytes using only a single film electrode (e.g., screen-printed electrode) instead of electrode arrays. It is of great potential in clinical analysis especially for multiple-biomarker detection, drug screening, and biological studies. Looking forward, we believe that more ECL devices and related ECL materials and detection methods will be developed for a wide range of applications, such as in vitro diagnosis, point-of-care testing, high-throughput analysis, drug screening, biological study, and mechanism investigation.
dc.description.sponsorshipConversion lumineuse par électrochimiluminescence photoinduite - ANR-20-CE29-0006en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCarbohydrates
dc.subject.enDiodes
dc.subject.enElectrochemical cells
dc.subject.enElectrodes
dc.subject.enPower
dc.title.enRational Design of Electrochemiluminescent Devices
dc.typeArticle de revueen_US
dc.identifier.doi10.1021/acs.accounts.1c00230en_US
dc.subject.halChimieen_US
dc.identifier.pubmed34165296en_US
bordeaux.journalAccounts of Chemical Researchen_US
bordeaux.page2936-2945en_US
bordeaux.volume54en_US
bordeaux.hal.laboratoriesInstitut des Sciences Moléculaires (ISM) - UMR 5255en_US
bordeaux.issue14en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.identifierhal-03812430
hal.version1
hal.date.transferred2022-10-12T14:27:07Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Accounts%20of%20Chemical%20Research&rft.date=2021-07-20&rft.volume=54&rft.issue=14&rft.spage=2936-2945&rft.epage=2936-2945&rft.eissn=0001-4842&rft.issn=0001-4842&rft.au=MA,%20Xiangui&GAO,%20Wenyue&DU,%20Fangxin&YUAN,%20Fan&YU,%20Jing&rft.genre=article


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