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dc.rights.licenseopenen_US
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorPAGANO, Paolo
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorROSENDALE, Morgane
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorDANIEL, Jonathan
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorVERLHAC, Jean-Baptiste
IDREF: 034239642
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorBLANCHARD DESCE, Mireille
dc.date.accessioned2022-10-12T13:49:26Z
dc.date.available2022-10-12T13:49:26Z
dc.date.issued2021-11-25
dc.identifier.issn1932-7447en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/158442
dc.description.abstractEnFluorescent Organic Nanoparticles (FONs) are light-emitting, molecular-based nanoparticles that can be obtained from the nanoprecipitation of dedicated hydrophobic organic dyes in water. They represent a versatile family of water-soluble fluorescent nanotools whose luminescent properties can be tuned by bottom-up molecular engineering of their composing dyes. We recently reported on a quadrupolar red-emitting dye that yields spontaneously stealthy bare FONs which do not require coating to hinder interactions with cell membranes. Its quadrupolar design also hints to the possibility that it may be a strong two-photon absorber for bioimaging purposes. In this paper, we further investigate the two-photon absorption (2PA) of this dye and resulting FONs and report on a structure-related series of extended dyes engineered to yield NIR-emitting FONs. All dyes lead to stable, small (12–20 nm in diameter), and bright FONs. The experimental study reveals that molecular confinement strongly influences the fluorescence and 2PA properties of these dyes depending on the nature of the π-extended system. As expected, extension of the π-conjugated system induces a red-shift of the absorption and emission bands as well as an increase and spectral broadening of the 2PA responses in solution. Upon aggregation of the dyes within nanoparticles, a reduction of the fluorescence quantum yield is observed whose amplitude depends strongly on the nature of the π-conjugated systems. Interestingly, the peak 2PA cross sections increase upon confinement of the shortest dye, while a spectral broadening and slight red shift of the 2PA bands of the most extended dyes is observed. Taken together, these properties allow the most extended dye to yield very bright NIR-emitting FONs (εmaxΦ = 7 × 106 M–1 cm–1, σ2maxΦ = 4 × 105 GM). Interestingly, the nature of the π-conjugated system was also found to modulate the stealthiness of the resulting nanoparticles toward biological membranes. As a result, by fine-tuning the molecular design of the quadrupolar FON-composing dyes, we achieved NIR-absorbing, NIR-emitting, spontaneously stealthy small nanoparticles having record one- and two-photon brightness. Finally, we demonstrate that these FONs can be noncovalently surface-coated with a polycationic polymer, thanks to their highly negative surface potentials. This induces a reversal of their surface potential which in turn triggers their internalization within cells.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAbsorption
dc.subject.enDyes and pigments
dc.subject.enFluorescence
dc.subject.enNanoparticles
dc.subject.enQuantum mechanics
dc.title.enUltrabright Red to NIR Emitting Fluorescent Organic Nanoparticles Made from Quadrupolar Dyes with Giant Two-Photon Absorption (2PA) in the NIR Region. Confinement Effect on Fluorescence and 2PA and Tuning of Surface Properties
dc.typeArticle de revueen_US
dc.identifier.doi10.1021/acs.jpcc.1c07831en_US
dc.subject.halChimieen_US
bordeaux.journalThe Journal of Physical Chemistry Cen_US
bordeaux.page25695-25705en_US
bordeaux.volume125en_US
bordeaux.hal.laboratoriesInstitut des Sciences Moléculaires (ISM) - UMR 5255en_US
bordeaux.issue46en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.identifierhal-03457942
hal.version1
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Journal%20of%20Physical%20Chemistry%20C&rft.date=2021-11-25&rft.volume=125&rft.issue=46&rft.spage=25695-25705&rft.epage=25695-25705&rft.eissn=1932-7447&rft.issn=1932-7447&rft.au=PAGANO,%20Paolo&ROSENDALE,%20Morgane&DANIEL,%20Jonathan&VERLHAC,%20Jean-Baptiste&BLANCHARD%20DESCE,%20Mireille&rft.genre=article


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