Afficher la notice abrégée

Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

dc.rights.licenseopenen_US
dc.contributor.authorKLEINSTERN, G.
dc.contributor.authorCAMP, N. J.
dc.contributor.authorGOLDIN, L. R.
dc.contributor.authorVACHON, C. M.
dc.contributor.authorVAJDIC, C. M.
dc.contributor.authorDE SANJOSE, S.
dc.contributor.authorWEINBERG, J. B.
dc.contributor.authorBENAVENTE, Y.
dc.contributor.authorCASABONNE, D.
dc.contributor.authorLIEBOW, M.
dc.contributor.authorNIETERS, A.
dc.contributor.authorHJALGRIM, H.
dc.contributor.authorMELBYE, M.
dc.contributor.authorGLIMELIUS, B.
dc.contributor.authorADAMI, H. O.
dc.contributor.authorBOFFETTA, P.
dc.contributor.authorBRENNAN, P.
dc.contributor.authorMAYNADIE, M.
dc.contributor.authorMCKAY, J.
dc.contributor.authorCOCCO, P. L.
dc.contributor.authorSHANAFELT, T. D.
dc.contributor.authorCALL, T. G.
dc.contributor.authorNORMAN, A. D.
dc.contributor.authorHANSON, C.
dc.contributor.authorROBINSON, D.
dc.contributor.authorCHAFFEE, K. G.
dc.contributor.authorBROOKS-WILSON, A. R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.contributor.authorCLAVEL, J.
dc.contributor.authorGLENN, M.
dc.contributor.authorCURTIN, K.
dc.contributor.authorCONDE, L.
dc.contributor.authorBRACCI, P. M.
dc.contributor.authorMORTON, L. M.
dc.contributor.authorCOZEN, W.
dc.contributor.authorSEVERSON, R. K.
dc.contributor.authorCHANOCK, S. J.
dc.contributor.authorSPINELLI, J. J.
dc.contributor.authorJOHNSTON, J. B.
dc.contributor.authorROTHMAN, N.
dc.contributor.authorSKIBOLA, C. F.
dc.contributor.authorLEIS, J. F.
dc.contributor.authorKAY, N. E.
dc.contributor.authorSMEDBY, K. E.
dc.contributor.authorBERNDT, S. I.
dc.contributor.authorCERHAN, J. R.
dc.contributor.authorCAPORASO, N.
dc.contributor.authorSLAGER, S. L.
dc.date.accessioned2020-11-23T11:06:36Z
dc.date.available2020-11-23T11:06:36Z
dc.date.issued2018-06-07
dc.identifier.issn1528-0020 (Electronic) 0006-4971 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/15569
dc.description.abstractEnInherited loci have been found to be associated with risk of chronic lymphocytic leukemia (CLL). A combined polygenic risk score (PRS) of representative single nucleotide polymorphisms (SNPs) from these loci may improve risk prediction over individual SNPs. Herein, we evaluated the association of a PRS with CLL risk and its precursor, monoclonal B-cell lymphocytosis (MBL). We assessed its validity and discriminative ability in an independent sample and evaluated effect modification and confounding by family history (FH) of hematological cancers. For discovery, we pooled genotype data on 41 representative SNPs from 1499 CLL and 2459 controls from the InterLymph Consortium. For validation, we used data from 1267 controls from Mayo Clinic and 201 CLL, 95 MBL, and 144 controls with a FH of CLL from the Genetic Epidemiology of CLL Consortium. We used odds ratios (ORs) to estimate disease associations with PRS and c-statistics to assess discriminatory accuracy. In InterLymph, the continuous PRS was strongly associated with CLL risk (OR, 2.49; P = 4.4 x 10(-94)). We replicated these findings in the Genetic Epidemiology of CLL Consortium and Mayo controls (OR, 3.02; P = 7.8 x 10(-30)) and observed high discrimination (c-statistic = 0.78). When jointly modeled with FH, PRS retained its significance, along with FH status. Finally, we found a highly significant association of the continuous PRS with MBL risk (OR, 2.81; P = 9.8 x 10(-16)). In conclusion, our validated PRS was strongly associated with CLL risk, adding information beyond FH. The PRS provides a means of identifying those individuals at greater risk for CLL as well as those at increased risk of MBL, a condition that has potential clinical impact beyond CLL.
dc.language.isoENen_US
dc.subject.enEPICENE
dc.title.enAssociation of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis
dc.title.alternativeBlooden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1182/blood-2017-11-814608en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29674426en_US
bordeaux.journalBlooden_US
bordeaux.page2541-2551en_US
bordeaux.volume131en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue23en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Blood&rft.date=2018-06-07&rft.volume=131&rft.issue=23&rft.spage=2541-2551&rft.epage=2541-2551&rft.eissn=1528-0020%20(Electronic)%200006-4971%20(Linking)&rft.issn=1528-0020%20(Electronic)%200006-4971%20(Linking)&rft.au=KLEINSTERN,%20G.&CAMP,%20N.%20J.&GOLDIN,%20L.%20R.&VACHON,%20C.%20M.&VAJDIC,%20C.%20M.&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée