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hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorRAVEL, Guillaume
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModeling Enablers for Multi-PHysics and InteractionS [MEMPHIS]
dc.contributor.authorBERGMANN, Michel
hal.structure.identifierMathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] [MaIAGE]
dc.contributor.authorTRUBUIL, Alain
hal.structure.identifierMICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
dc.contributor.authorDESCHAMPS, Julien
hal.structure.identifierMICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
dc.contributor.authorBRIANDET, Romain
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
hal.structure.identifierMathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] [MaIAGE]
hal.structure.identifierUniversité Paris-Saclay
hal.structure.identifierPleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
dc.contributor.authorLABARTHE, Simon
dc.date.conference2022-09-08
dc.description.abstractEnBiofilms are spatially organized communities of microorganisms embedded in a self-produced organic matrix, conferring to the population emerging properties such as an increased tolerance to the action of antimicrobials. It was shown that some bacilli were able to swim in the exogenous matrix of pathogenic biofilms and to counterbalance these properties. Swimming bacteria can deliver antimicrobial agents in situ, or potentiate the activity of antimicrobial by creating a transient vascularization network in the matrix. Hence, characterizing swimmer trajectories in the biofilm matrix is of particular interest to understand and optimize this new biocontrol strategy in particular, but also more generally to decipher ecological drivers of population spatial structure in natural biofilms ecosystems. In this study, a new methodology is developed to analyze time-lapse confocal laser scanning images to describe and compare the swimming trajectories of bacilli swimmers populations and their adaptations to the biofilm structure. The method is based on the inference of a kinetic model of swimmer populations including mechanistic interactions with the host biofilm. After validation on synthetic data, the methodology is implemented on images of three different species of motile bacillus species swimming in a Staphylococcus aureus biofilm. The fitted model allows to stratify the swimmer populations by their swimming behavior and provides insights into the mechanisms deployed by the micro-swimmers to adapt their swimming traits to the biofilm matrix.
dc.description.sponsorshipSensibilisation de biofilms industriels à l'action de désinfectants par l'infiltration de bactéries hyper-motiles - ANR-12-ALID-0006
dc.language.isoen
dc.subject.enbacterial swimmers
dc.subject.enbiofilm
dc.subject.encomputational biology
dc.subject.enconfocal microscopy
dc.subject.eninferrence
dc.subject.enmodelling
dc.subject.ensystems biology
dc.title.enInferring characteristics of bacterial swimming in biofilm matrix from time-lapse confocal laser scanning microscopy
dc.typeCommunication dans un congrès
dc.identifier.doi10.7554/eLife.76513
dc.subject.halSciences du Vivant [q-bio]
bordeaux.conference.titleIbSB 2022 - 6th International Symposium "Image-based Systems Biology"
bordeaux.countryDE
bordeaux.conference.cityJena
bordeaux.peerReviewedoui
hal.identifierhal-03753533
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2022-09-09
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03753533v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=RAVEL,%20Guillaume&BERGMANN,%20Michel&TRUBUIL,%20Alain&DESCHAMPS,%20Julien&BRIANDET,%20Romain&rft.genre=unknown


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