LE TREQUESSER, Quentin; SAEZ, Gladys; DEVÈS, Guillaume; BARBERET, Philippe; MICHELET, C.; DELVILLE, Marie-Hélène; SEZNEC, Hervé

doi:10.1016/j.nimb.2014.06.031

Metadatos

Licencia de uso del documento

LE TREQUESSER, Quentin
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Interface Physique et Chimie pour le Vivant [IPCV]

SAEZ, Gladys
Interface Physique et Chimie pour le Vivant [IPCV]

DEVÈS, Guillaume
Interface Physique et Chimie pour le Vivant [IPCV]

Idioma

Article de revue

Este ítem está publicado en

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2014, vol. 341, p. 58-64

Elsevier

Resumen en inglés

Detecting and tracking nanomaterials in biological systems is challenging and essential to understand the possible interactions with the living. In this context, in situ analyses were conducted on human skin cells and a multicellular organism (Caenorhabditiselegans) exposed to titanium dioxide nanoparticles (TiO2 NPs) using nuclear microprobe. Coupled to conventional methods, nuclear microprobe was found to be suitable for accurate description of chemical structure of biological systems and also for detection of native TiO2 NPs. The method presented herein opens the field to NPs exposure effects analyses and more generally to toxicological analyses assisted by nuclear microprobe. This method will show applications in key research areas where in situ imaging of chemical elements is essential.< Leer menos

Palabras clave en inglés

Nanoparticles

Nuclear microprobe

In situ quantitative analysis

Multicellular specimens/C. elegans

Human cells

DOI

http://dx.doi.org/10.1016/j.nimb.2014.06.031

Proyecto ANR

Mécanismes d'internalisation et de toxicité des nanoparticules d'oxyde de titane dans des organismes multicellulaires eucaryotes - ANR-10-CESA-0009

Orígen

Importado de Hal

Centros de investigación

Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB) - UMR 5026