Mostrar el registro sencillo del ítem

Synthesis of 1,4-disubstituted pyrido[1′,2′:1,5]pyrazolo[3,4-d]pyridazines by means of SNAr and palladium-catalysed reactions

hal.structure.identifierInstitut de Chimie Organique et Analytique [ICOA]
hal.structure.identifierLaboratoire de Chimie, Bioorganique et analytique
dc.contributor.authorBELAROUSSI, Rabia
dc.contributor.authorEL HAKMAOUI, Ahmed
hal.structure.identifierInstitut de Chimie Organique et Analytique [ICOA]
dc.contributor.authorPERCINA, Nathalie
hal.structure.identifierInstitut de Chimie Organique et Analytique [ICOA]
dc.contributor.authorCHARTIER, Agnès
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARCHIVIE, Mathieu
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorMASSIP, Stéphane
hal.structure.identifierLaboratoire de Pharmacochimie
dc.contributor.authorJARRY, Christian
hal.structure.identifierLaboratoire de Chimie, Bioorganique et analytique
dc.contributor.authorAKSSIRA, Mohamed
hal.structure.identifierInstitut de Chimie Organique et Analytique [ICOA]
dc.contributor.authorGUILLAUMET, Gérald
hal.structure.identifierInstitut de Chimie Organique et Analytique [ICOA]
dc.contributor.authorROUTIER, Sylvain
dc.date.issued2015
dc.identifier.issn1434-1948
dc.description.abstractEnThe first efficient synthesis of various 1,4-disubstituted pyrido[1′,2′:1,5]pyrazolo[3,4-d]pyridazines is reported. The reactivity toward chlorine release at the C-1 and C-4 positions was investigated. SNAr and palladium-catalysed cross-coupling reactions were carried out, and conditions were optimised for each procedure. 1,4-Bis(het)aryl derivatives were obtained under a Suzuki cross-coupling procedure whereas SNAr substitution was achieved mainly at C-1 in preference to C-4. The monosubstituted C-4 morpholino derivative was used as a starting material to provide dissymmetrical 1,4-diaminated or 1-(het)aryl-4-morpholino products.
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.subject.enNitrogen heterocycles
dc.subject.enCross-coupling
dc.subject.enAromatic nucleophilic substitution
dc.subject.enPalladium
dc.title.enSynthesis of 1,4-disubstituted pyrido[1′,2′:1,5]pyrazolo[3,4-d]pyridazines by means of SNAr and palladium-catalysed reactions
dc.typeArticle de revue
dc.identifier.doi10.1002/ejoc.201500294
dc.subject.halChimie/Matériaux
bordeaux.journalEuropean Journal of Inorganic Chemistry
bordeaux.page4006-4017
bordeaux.issue18
bordeaux.peerReviewedoui
hal.identifierhal-01166893
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01166893v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Inorganic%20Chemistry&rft.date=2015&rft.issue=18&rft.spage=4006-4017&rft.epage=4006-4017&rft.eissn=1434-1948&rft.issn=1434-1948&rft.au=BELAROUSSI,%20Rabia&EL%20HAKMAOUI,%20Ahmed&PERCINA,%20Nathalie&CHARTIER,%20Agn%C3%A8s&MARCHIVIE,%20Mathieu&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem