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Influence of isomerism on recrystallization and cocrystallization induced by CO2 as an antisolvent

hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorHARSCOAT-SCHIAVO, Christelle
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorNEUROHR, Clémence
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLECOMTE, Sophie
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARCHIVIE, Mathieu
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorSUBRA-PATERNAULT, Pascale
dc.date.issued2015
dc.description.abstractEnMicronization, polymorphism, and cocrystal formation are well-known strategies to modify the characteristics of pharmaceutical ingredients. In this work, recrystallization induced by compressed CO2 as an antisolvent was investigated as a new way to produce aminosalicylate (ASA) polymorphs and cocrystals. Three ASA isomers were first recrystallized as single species. Isomerism has a particular influence on the product characteristics. The 5-ASA isomer was produced as micrometric spherical crystals with improved flow properties but no change in the crystal lattice was observed. 3-ASA recrystallized as micrometric spheres in a less dense crystal packing than that of the raw compound, and the 4-ASA isomer did not exhibit noticeable changes in the morphology or crystal lattice. Cocrystallization of each isomer with nicotinamide resulted in the production of an ASA:NCTA cocrystal only in the case of 4-ASA.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.title.enInfluence of isomerism on recrystallization and cocrystallization induced by CO2 as an antisolvent
dc.typeArticle de revue
dc.identifier.doi10.1039/c5ce00753d
dc.subject.halChimie/Matériaux
bordeaux.journalCrystEngComm
bordeaux.page5410-5421
bordeaux.volume17
bordeaux.issue29
bordeaux.peerReviewedoui
hal.identifierhal-01193299
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01193299v1
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