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Process intensification for the synthesis of ultra-small organic nanoparticles with supercritical CO2 in a microfluidic system

hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorJAOUHARI, Thomas
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorZHANG, Fan
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorTASSAING, Thierry
hal.structure.identifierSynthèse et Physico-Chimie de Molécules d'Intérêt Biologique [SPCMIB]
dc.contributor.authorFERY-FORGUES, Suzanne
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorAYMONIER, Cyril
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARRE, Samuel
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorERRIGUIBLE, Arnaud
dc.date.issued2020
dc.identifier.issn1385-8947
dc.description.abstractEnSubmicronization of organic compounds is a challenging requirement for applications in the imaging and pharmaceutical fields. A new Supercritical AntiSolvent process with microreactor (µSAS) was developed for nanoparticle (NP) synthesis. Tetrahydrofuran (THF) was used to solubilize a model organic molecule, tetraphenylethylene, and supercritical carbon dioxide (sc-CO2) was used as antisolvent. The solubility of TPE in the THF/CO2 system was first measured by in situ experiments. Then, NPs of TPE were prepared in various experimental conditions and characterized by transmission electron microscopy (TEM). Chosen experimental conditions led to NPs with a mean size of 9 ± 3 nm. Experimental µSAS results were compared with size distributions obtained by simulation, to obtain surface tension values, which are difficult to access by experiment alone. Simulations coupling Computational Fluid Dynamics (CFD) and Population Balance Equation (PBE) were performed under turbulent conditions in the high pressure microreactors. This coupled experimental and theoretical approach allowed a deep understanding of the µSAS process and underlined the superior value of this technique for the preparation of NPs.
dc.description.sponsorshipSynthèse de nanocristaux organiques fluorescents en milieu fluide supercritique: une approche numérique et expérimentale complémentaire - ANR-17-CE07-0029
dc.language.isoen
dc.publisherElsevier
dc.subject.enMicrofluidic
dc.subject.enSupercritical fluid
dc.subject.enNanoparticle synthesis
dc.subject.enNumerical simulation
dc.subject.enMixing intensification
dc.title.enProcess intensification for the synthesis of ultra-small organic nanoparticles with supercritical CO2 in a microfluidic system
dc.typeArticle de revue
dc.identifier.doi10.1016/j.cej.2020.125333
dc.subject.halChimie/Matériaux
bordeaux.journalChemical Engineering Journal
bordeaux.page125333
bordeaux.volume397
bordeaux.peerReviewedoui
hal.identifierhal-02768081
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02768081v1
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