Nanoparticle-lipid interaction: job scattering plots to differentiate vesicle aggregation from supported lipid bilayer formation
Language
en
Article de revue
This item was published in
Colloids and Interfaces. 2018, vol. 2, n° 4, p. 50
MDPI
English Abstract
The impact of nanomaterials on lung fluids, or on the plasma membrane of living cells, has prompted researchers to examine the interactions between nanoparticles and lipid vesicles. Recent studies have shown that ...Read more >
The impact of nanomaterials on lung fluids, or on the plasma membrane of living cells, has prompted researchers to examine the interactions between nanoparticles and lipid vesicles. Recent studies have shown that nanoparticle-lipid interaction leads to a broad range of structures including supported lipid bilayers (SLB), particles adsorbed at the surface or internalized inside vesicles, and mixed aggregates. Currently, there is a need to have simple protocols that can readily evaluate the structures made from particles and vesicles. Here we apply the method of continuous variation for measuring Job scattering plots and provide analytical expressions for the scattering intensity in various scenarios. The result that emerges from the comparison between experiments and modeling is that electrostatics play a key role in the association, but it is not sufficient to induce the formation of supported lipid bilayers.Read less <
English Keywords
Nanoparticles
Bio-nano interfaces
Electrostatic interactions
Supported lipid bilayers
nanoparticles
bio-nano interfaces
electrostatic interactions
supported lipid bilayers
ANR Project
Science and Engineering for Advanced Materials and devices
Université Sorbonne Paris Cité
Assemblage Macromoléculaire Hors-équilibre Compréhension, Contrôle & nouvelles structures
Interactions des nanoparticules avec des surfaces mimétiques des poumons et du liquide pulmonaire
Nanoparticules d'oxyde de cérium recouvertes de polymères industriels innovants pour le traitement des accidents vasculaires cérébraux
Université Sorbonne Paris Cité
Assemblage Macromoléculaire Hors-équilibre Compréhension, Contrôle & nouvelles structures
Interactions des nanoparticules avec des surfaces mimétiques des poumons et du liquide pulmonaire
Nanoparticules d'oxyde de cérium recouvertes de polymères industriels innovants pour le traitement des accidents vasculaires cérébraux
Origin
Hal imported