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Gd- and Eu-loaded iron oxide@silica core–shell nanocomposites as trimodal contrast agents for magnetic resonance imaging and optical imaging

hal.structure.identifierCenter for Research in Ceramic and Composite Materials [CICECO]
hal.structure.identifierCenter for Neurosciences and Cell Biology
hal.structure.identifierVasco da Gama Research Center
dc.contributor.authorPINHO, Sonia
hal.structure.identifierInstituto de Ciências Nucleares Aplicadas à Saúde [CIBIT/ICNAS]
dc.contributor.authorSERENO, José
hal.structure.identifierInstituto de Ciências Nucleares Aplicadas à Saúde [CIBIT/ICNAS]
dc.contributor.authorABRUNHOSA, Antero
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDELVILLE, Marie-Hélène
hal.structure.identifierUniversidade de Aveiro
hal.structure.identifierCenter for Research in Ceramic and Composite Materials [CICECO]
dc.contributor.authorROCHA, João
hal.structure.identifierUniversidade de Aveiro
hal.structure.identifierCenter for Research in Ceramic and Composite Materials [CICECO]
dc.contributor.authorCARLOS, Luis
hal.structure.identifierDepartment of Life Sciences
hal.structure.identifierInstituto de Ciências Nucleares Aplicadas à Saúde [CIBIT/ICNAS]
hal.structure.identifierChemistry Center
dc.contributor.authorGERALDES, Carlos
dc.date.issued2019
dc.identifier.issn0020-1669
dc.description.abstractEnSuperparamagnetic maghemite core–porous silica shell nanoparticles, γ-Fe2O3@SiO2 (FS), with 50 nm diameter and a 10 nm core, impregnated with paramagnetic complexes b-Ln ([Ln(btfa)3(H2O)2]) (where btfa = 4,4,4-trifluoro-l-phenyl-1,3-butanedione and Ln = Gd, Eu, and Gd/Eu), performing as promising trimodal T1–T2 MRI and optical imaging contrast agents, are reported. These nanosystems exhibit a high dispersion stability in water and no observable cytotoxic effects, witnessed by intracellular ATP levels. The structure and superparamagnetic properties of the maghemite core nanocrystals are preserved upon imbedding the b-Ln complexes in the shell. Hela cells efficiently and swiftly internalize the NPs into the cytosol, with no observable cytotoxicity below a concentration of 62.5 μg mL–1. These nanosystems perform better than the free b-Gd complex as T1 (positive) contrast agents in cellular pellets, while their performance as T2 (negative) contrast agents is similar to the FS. Embedding of the b-Eu complex in the silica pores endows the nanoparticles with strong luminescence properties. The impregnation of gadolinium and europium complexes in a 1:1 ratio afforded a trimodal nanoplatform performing as a luminescent probe and a double T1 and T2 MRI contrast agent even more efficient than b-Gd used on its own, as observed in cell-labeled imaging experiments and MRI cell pellets.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.title.enGd- and Eu-loaded iron oxide@silica core–shell nanocomposites as trimodal contrast agents for magnetic resonance imaging and optical imaging
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.inorgchem.9b02655
dc.subject.halChimie/Matériaux
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
bordeaux.journalInorganic Chemistry
bordeaux.page16618-16628
bordeaux.volume58
bordeaux.issue24
bordeaux.peerReviewedoui
hal.identifierhal-02416633
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02416633v1
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