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Transfer and Transcriptomic Profiling in Liver and Brain of European Eels ( Anguilla anguilla ) After Diet‐borne Exposure to Gold Nanoparticles

hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPERRIER, Fanny
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBERTUCCI, Anthony
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPIERRON, Fabien
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorFEURTET‐MAZEL, Agnès
hal.structure.identifierLaboratoire d'écotoxicologie des radionucléides [IRSN/PRP-ENV/SERIS/LECO]
dc.contributor.authorSIMON, Olivier
hal.structure.identifierPlateforme Bio-Informatique - Génotoul
dc.contributor.authorKLOPP, Christophe
hal.structure.identifierGéosciences Environnement Toulouse [GET]
dc.contributor.authorCANDAUDAP, Frédéric
hal.structure.identifierGéosciences Environnement Toulouse [GET]
dc.contributor.authorPOKROVSKI, Oleg
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorETCHEVERRIA, Bruno
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stéphane
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBAUDRIMONT, Magalie
dc.date.issued2020
dc.identifier.issn0730-7268
dc.description.abstractEnA nanometric revolution is underway, promising technical innovations in a wide range of applications and leading to a potential boost in environmental discharges. The propensity of nanoparticles (NPs) to be transferred throughout trophic chains and to generate toxicity was mainly assessed in primary consumers, whereas a lack of knowledge for higher trophic levels persists. The present study focused on a predatory fish, the European eel (Anguilla anguilla) exposed to gold NPs (AuNPs; 10 nm, polyethylene glycol–coated) for 21 d at 3 concentration levels in food: 0 (NP0), 1 (NP1), and 10 (NP10) mg Au kg−1. Transfer was assessed by Au quantification in eel tissues, and transcriptomic responses in the liver and brain were revealed by a high‐throughput RNA‐sequencing approach. Eels fed at NP10 presented an erratic feeding behavior, whereas Au quantification only indicated transfer to intestine and kidney of NP1‐exposed eels. Sequencing of RNA was performed in NP0 and NP1 eels. A total of 258 genes and 156 genes were significantly differentially transcribed in response to AuNP trophic exposure in the liver and brain, respectively. Enrichment analysis highlighted modifications in the immune system–related processes in the liver. In addition, results pointed out a shared response of both organs regarding 13 genes, most of them being involved in immune functions. This finding may shed light on the mode of action and toxicity of AuNPs in fish.
dc.description.sponsorshipApproches à différentes échelles pour caractériser les interactions cellulaires, le transfert trophique et les impacts toxiques de nanoparticules métalliques chez les organismes aquatiques - ANR-14-CE21-0001
dc.description.sponsorshipCOntinental To coastal Ecosystems: evolution, adaptability and governance - ANR-10-LABX-0045
dc.language.isoen
dc.publisherWiley
dc.subject.enGold nanoparticles
dc.subject.enAnguilla anguilla
dc.subject.enRNAseq
dc.subject.endiet-borne exposure
dc.subject.enimmunity
dc.title.enTransfer and Transcriptomic Profiling in Liver and Brain of European Eels ( Anguilla anguilla ) After Diet‐borne Exposure to Gold Nanoparticles
dc.typeArticle de revue
dc.typeArticle de synthèse
dc.identifier.doi10.1002/etc.4858
dc.subject.halSciences du Vivant [q-bio]/Toxicologie/Ecotoxicologie
bordeaux.journalEnvironmental Toxicology and Chemistry
bordeaux.page2450-2461
bordeaux.volume39
bordeaux.issue12
bordeaux.peerReviewedoui
hal.identifierhal-02975506
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02975506v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Toxicology%20and%20Chemistry&rft.date=2020&rft.volume=39&rft.issue=12&rft.spage=2450-2461&rft.epage=2450-2461&rft.eissn=0730-7268&rft.issn=0730-7268&rft.au=PERRIER,%20Fanny&BERTUCCI,%20Anthony&PIERRON,%20Fabien&FEURTET%E2%80%90MAZEL,%20Agn%C3%A8s&SIMON,%20Olivier&rft.genre=article&unknown


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