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hal.structure.identifierRégulations Naturelles et Artificielles [ARNA]
dc.contributor.authorGUILLON, Jean
hal.structure.identifierRégulations Naturelles et Artificielles [ARNA]
hal.structure.identifierDepartment of Pharmacy and CIRPeB
dc.contributor.authorVINCENZI, Marian
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorPINAUD, Noël
hal.structure.identifierRégulations Naturelles et Artificielles [ARNA]
dc.contributor.authorRONGA, Luisa
dc.contributor.authorROSSI, Filomena
hal.structure.identifierRégulations Naturelles et Artificielles [ARNA]
hal.structure.identifierDepartment of Pharmacy and CIRPeB
dc.contributor.authorSAVRIMOUTOU, Solène
hal.structure.identifierRégulations Naturelles et Artificielles [ARNA]
dc.contributor.authorMOREAU, Stéphane
hal.structure.identifierBiothérapies des maladies génétiques et cancers
dc.contributor.authorDESPLAT, Vanessa
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARCHIVIE, Mathieu
dc.date.issued2016
dc.identifier.issn2470-9905
dc.description.abstractEnThe X-ray crystal structure of 3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol- 1-yl)piperidin-1-yl)benzyl]}-2-phenylindole, a compound that showed high cytotoxic potential against various leukemia cell lines, was established. The 3D spatial determination confirmed the structure in the solid state. It crystallizes in the triclinic space group P-1 with cell parameters a=9.572(7) Å, b=11.091(2) Å, c=15.976(4) Å, α=92.53(2), β=105.45(3), γ=94.65(3), V=1625.6(13) Å3 and Z=2. The crystal structure was refined to final values of R1=0.0638 and wR2=0.1800. The crystal packing is controlled by intermolecular hydrogen bonding and C-H π interactions. In addition, these new data could be further used to clarify the mechanism of action, implicating the antiproliferative effect of this new synthetic indole derivative on human leukemic cells.
dc.language.isoen
dc.publisherInsight Medical Publishing
dc.subject.enAntiproliferative activity
dc.subject.enR factor
dc.subject.enSingle-crystal x-ray study
dc.subject.enIndole derivative
dc.title.enSynthesis and crystal structure of 3-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole
dc.typeArticle de revue
dc.identifier.doi10.21767/2470-9905.100018
dc.subject.halChimie/Chimie thérapeutique
dc.subject.halChimie/Cristallographie
bordeaux.journalStructural Chemistry & Crystallography Communication
bordeaux.page18
bordeaux.volume2
bordeaux.issue1
bordeaux.peerReviewedoui
hal.identifierhal-01432803
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01432803v1
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