Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis.
| hal.structure.identifier | Régulations Naturelles et Artificielles [ARNA] | |
| dc.contributor.author | OUMZIL, Khalid | |
| hal.structure.identifier | Régulations Naturelles et Artificielles [ARNA] | |
| dc.contributor.author | RAMIN, Michael A. | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | LORENZATO, Cyril | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | HÉMADOU, Audrey | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | LAROCHE, Jeanny | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | JACOBIN-VALAT, Marie Josée | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | MORNET, Stéphane | |
| hal.structure.identifier | Régulations Naturelles et Artificielles [ARNA] | |
| dc.contributor.author | ROY, Claude-Eric | |
| hal.structure.identifier | Régulations Naturelles et Artificielles [ARNA] | |
| dc.contributor.author | KAUSS, Tina | |
| hal.structure.identifier | Régulations Naturelles et Artificielles [ARNA] | |
| dc.contributor.author | GAUDIN, Karen | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | CLOFENT-SANCHEZ, Gisèle | |
| hal.structure.identifier | Régulations Naturelles et Artificielles [ARNA] | |
| dc.contributor.author | BARTHÉLÉMY, Philippe | |
| dc.date.issued | 2016-03-16 | |
| dc.identifier.issn | 1043-1802 | |
| dc.description.abstractEn | Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy. | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.title.en | Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis. | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1021/acs.bioconjchem.5b00590 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | Bioconjugate Chemistry | |
| bordeaux.page | 569-575 | |
| bordeaux.volume | 27 | |
| bordeaux.issue | 3 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01296329 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01296329v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bioconjugate%20Chemistry&rft.date=2016-03-16&rft.volume=27&rft.issue=3&rft.spage=569-575&rft.epage=569-575&rft.eissn=1043-1802&rft.issn=1043-1802&rft.au=OUMZIL,%20Khalid&RAMIN,%20Michael%20A.&LORENZATO,%20Cyril&H%C3%89MADOU,%20Audrey&LAROCHE,%20Jeanny&rft.genre=article |
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