Design of hybrid nanovehicles for remotely triggered drug release : an overview
LIU, Ji
Centre d'Etude et de Recherche sur les Macromolécules [CERM]
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
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Centre d'Etude et de Recherche sur les Macromolécules [CERM]
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
LIU, Ji
Centre d'Etude et de Recherche sur les Macromolécules [CERM]
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
< Leer menos
Centre d'Etude et de Recherche sur les Macromolécules [CERM]
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Idioma
en
Article de revue
Este ítem está publicado en
Journal of materials chemistry B. 2015, vol. 3, n° 30, p. 6117-6147
Royal Society of Chemistry
Resumen en inglés
In the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote stimuli, e.g. ...Leer más >
In the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote stimuli, e.g. alternating magnetic field, near infrared or ultrasound radiations, the release of guest molecules can be triggered in a quite controlled manner. Herein, we review different hybrid nanostructures which have already been reported for the remotely triggered release, such as those based on (1) host–guest conjugates, (2) core–corona nanoparticles, (3) polymer nanogels, (4) polymer micelles, (5) liposomes, (6) mesoporous silica particles and (7) hollow nanoparticles. Moreover, we also summarize six underlying mechanisms that govern such a kind of remotely triggered release behaviours: (1) enhanced diffusion and/or permeation, (2) thermo- or photo-labile bond cleavage, (3) fusion of phase-changed materials, (4) photo-induced isomerisation, (5) thermo-induced swelling/de-swelling of thermo-responsive polymers, and (6) destruction of the nanostructures. The ways in which different components are incorporated into an integrated hybrid nanostructure and how they contribute to the remotely triggered release behaviours are detailed.< Leer menos
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