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Pulsed field ablation selectively spares the oesophagus during pulmonary vein isolation for atrial fibrillation

dc.rights.licenseopenen_US
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCOCHET, Hubert
dc.contributor.authorNAKATANI, Yosuke
dc.contributor.authorSRIDI-CHENITI, Soumaya
dc.contributor.authorCHENITI, Ghassen
dc.contributor.authorRAMIREZ, F. Daniel
dc.contributor.authorNAKASHIMA, Takashi
dc.contributor.authorEGGERT, Charles
dc.contributor.authorSCHNEIDER, Christopher
dc.contributor.authorVISWANATHAN, Raju
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDERVAL, Nicolas
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDUCHATEAU, Josselin
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPAMBRUN, Thomas
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCHAUVEL, Remi
dc.contributor.authorREDDY, Vivek Y.
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorMONTAUDON, Michel
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorLAURENT, Francois
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorSACHER, Frederic
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHOCINI, Meleze
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHAISSAGUERRE, Michel
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorJAIS, Pierre
dc.date.accessioned2022-10-12T09:00:05Z
dc.date.available2022-10-12T09:00:05Z
dc.date.issued2021-09-01
dc.identifier.issn1099-5129en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/150929
dc.description.abstractEnExtra-atrial injury can cause complications after catheter ablation for atrial fibrillation (AF). Pulsed field ablation (PFA) has generated preclinical data suggesting that it selectively targets the myocardium. We sought to characterize extra-atrial injuries after pulmonary vein isolation (PVI) between PFA and thermal ablation methods.Cardiac magnetic resonance (CMR) imaging was performed before, acutely (<3 h) and 3 months post-ablation in 41 paroxysmal AF patients undergoing PVI with PFA (N = 18, Farapulse) or thermal methods (N = 23, 16 radiofrequency, 7 cryoballoon). Oesophageal and aortic injuries were assessed by using late gadolinium-enhanced (LGE) imaging. Phrenic nerve injuries were assessed from diaphragmatic motion on intra-procedural fluoroscopy. Baseline CMR showed no abnormality on the oesophagus or aorta. During ablation procedures, no patient showed phrenic palsy. Acutely, thermal methods induced high rates of oesophageal lesions (43%), all observed in patients showing direct contact between the oesophagus and the ablation sites. In contrast, oesophageal lesions were observed in no patient ablated with PFA (0%, P < 0.001 vs. thermal methods), despite similar rates of direct contact between the oesophagus and the ablation sites (P = 0.41). Acute lesions were detected on CMR on the descending aorta in 10/23 (43%) after thermal ablation, and in 6/18 (33%) after PFA (P = 0.52). CMR at 3 months showed a complete resolution of oesophageal and aortic LGE in all patients. No patient showed clinical complications. PFA does not induce any signs of oesophageal injury on CMR after PVI. Due to its tissue selectivity, PFA may improve safety for catheter ablation of AF.
dc.description.sponsorshipPlateforme multi-modale d'exploration en cardiologieen_US
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaqueen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enPulsed field ablation
dc.subject.enAtrial fibrillation
dc.subject.enCatheter ablation
dc.subject.enOesophagus
dc.subject.enCardiac magnetic resonance
dc.title.enPulsed field ablation selectively spares the oesophagus during pulmonary vein isolation for atrial fibrillation
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/europace/euab090en_US
dc.subject.halSciences de l'ingénieur [physics]en_US
dc.identifier.pubmed33961027en_US
dc.description.sponsorshipEuropeElectrostructural Tomography - Towards Multiparametric Imaging of Cardiac Electrical Disordersen_US
bordeaux.journalEP-Europaceen_US
bordeaux.page1391-1399en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesCentre de Recherche Cardio-Thoracique de Bordeaux (CRCTB) - U 1045en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDEuropean Research Councilen_US
hal.identifierhal-03811828
hal.version1
hal.date.transferred2022-10-12T09:00:09Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EP-Europace&rft.date=2021-09-01&rft.volume=23&rft.issue=9&rft.spage=1391-1399&rft.epage=1391-1399&rft.eissn=1099-5129&rft.issn=1099-5129&rft.au=COCHET,%20Hubert&NAKATANI,%20Yosuke&SRIDI-CHENITI,%20Soumaya&CHENITI,%20Ghassen&RAMIREZ,%20F.%20Daniel&rft.genre=article


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