Design of polypeptide-functionalized polystyrene microspheres
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| dc.contributor.author | BOUSQUET, Antoine | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| dc.contributor.author | PERRIER-CORNET, Romain | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| dc.contributor.author | IBARBOURE, Emmanuel | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| hal.structure.identifier | Team 1 LCPO : Polymerization Catalyses & Engineering | |
| dc.contributor.author | PAPON, Eric | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | LABRUGÈRE, Christine | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| hal.structure.identifier | Team 1 LCPO : Polymerization Catalyses & Engineering | |
| dc.contributor.author | HÉROGUEZ, Valérie | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| dc.contributor.author | RODRIGUEZ-HERNANDEZ, Juan | |
| dc.date.issued | 2008 | |
| dc.identifier.issn | 1525-7797 | |
| dc.description.abstractEn | In this contribution, the principle of spontaneous surface segregation has been applied for the preparation of polypeptide-functionalized polystyrene microspheres. For that purpose, an amphiphilic diblock copolymer was introduced in the mixture styrene/divinylbenzene and polymerized using AIBN as initiator. During the polymerization, cross-linked particles were obtained in which the diblock copolymer was encapsulated. The amphiphilic diblock copolymers used throughout this study contain a hydrophilic polypeptide segment, either poly(L-lysine) or poly(L-glutamic acid) and a hydrophobic polystyrene block. After 4 h of polymerization, rather monodisperse particles with sizes of ∼3-4 μm were obtained. Upon annealing in hot water, the hydrophilic polypeptides migrate to the interface, hence, either positively charged or neutral particles were obtained when poly(L-lysine) is revealed at the surface and exposed to acidic or basic pH, respectively. On the opposite, negatively charged particles were achieved in basic pH water by using poly(L-glutamic acid) as additive. The surface chemical composition was modified by changing the environment of the particles. Thus, exposure in toluene provoked a surface rearrangement, and due to its affinity, the polystyrene block reorients toward the interface. | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.subject.en | Polystyrene | |
| dc.subject.en | Functionalized materials | |
| dc.subject.en | Microspheres | |
| dc.subject.en | LATEX-PARTICLES | |
| dc.subject.en | PRECIPITATION POLYMERIZATION | |
| dc.subject.en | DIVINYL BENZENE) MICROSPHERES | |
| dc.subject.en | TRANSFER RADICAL POLYMERIZATION | |
| dc.subject.en | POLY(L-LYSINE) | |
| dc.subject.en | METHACRYLATE | |
| dc.subject.en | TRANSITION | |
| dc.subject.en | MORPHOLOGY | |
| dc.subject.en | BLOCK-COPOLYMERS | |
| dc.subject.en | NANOPARTICLES | |
| dc.title.en | Design of polypeptide-functionalized polystyrene microspheres | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1021/bm8000292 | |
| dc.subject.hal | Chimie/Matériaux | |
| dc.subject.hal | Chimie/Polymères | |
| bordeaux.journal | Biomacromolecules | |
| bordeaux.page | 1811-1817 | |
| bordeaux.volume | 9 | |
| bordeaux.issue | 7 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00322870 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00322870v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2008&rft.volume=9&rft.issue=7&rft.spage=1811-1817&rft.epage=1811-1817&rft.eissn=1525-7797&rft.issn=1525-7797&rft.au=BOUSQUET,%20Antoine&PERRIER-CORNET,%20Romain&IBARBOURE,%20Emmanuel&PAPON,%20Eric&LABRUG%C3%88RE,%20Christine&rft.genre=article |
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